Marine sponge compounds with antiplasmodial properties: Focus on in vitro study against Plasmodium falciparum

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dc.contributor.authorHikmawan, Baso Didiken_US
dc.contributor.authorSubagus, Wahyuonoen_US
dc.contributor.authorErna, Prawita Setyowatien_US
dc.date.accessioned2020-10-16T08:56:57Z
dc.date.available2020-10-16T08:56:57Z
dc.date.issued2020-05
dc.description.abstractMalaria continues to be a major cause of morbidity and mortality in many tropical countries. The lack of progressin drug discovery and the spread of drug resistance become the reason behind this. Porifera (sponges) is a potentialsource of novel bioactive compounds to provide future drugs against malaria. In this review, we summarized 243isolated molecules belonging to 35 different genera that active against Plasmodium falciparum from published paperuntil March 2019. The molecules were classified into potent, good, moderate, low, and inactive based on their IC50, andamong observed bioactive metabolites, there were 57 marine sponge molecules reported to act as potent antiplasmodiumagainst various strains of P. falciparum including drug resistance and nondrug resistance. Table 2 represents the listof isolated compounds with “potent” antimalarial activity. The class of the listed compounds includes manzaminealkaloid, guanidine alkaloids, bispyrroloiminoquinone alkaloids, pyrroloiminoquinone alkaloids, ingamine alkaloids,bromotyrosine alkaloids, sesquiterpenoids, diterpene formamides, aminoimidazole, β-galactosylceramides, β-lactam,meroterpene, trisoxazole macrolides, peroxides, thiazine alkaloids, and sterols. With this up-to-date review, we attemptto present new perspectives for the rational discovery of novel sponge metabolites that can be used as lead compoundsin antimalarial drug development.en_US
dc.identifier.affiliationsMaster of Pharmaceutical Science Program, Faculty of Pharmacy, Universitas Gadjah Mada, Yogyakarta 55281, Indonesiaen_US
dc.identifier.affiliationsDepartment of Pharmaceutical Biology, Faculty of Pharmacy, Universitas Gadjah Mada, Yogyakarta 55281, Indonesiaen_US
dc.identifier.affiliationsDepartment of Pharmaceutical Biology, Faculty of Pharmacy, Universitas Gadjah Mada, Yogyakarta 55281, Indonesiaen_US
dc.identifier.citationHikmawan Baso Didik, Subagus Wahyuono, Erna Prawita Setyowati. Marine sponge compounds with antiplasmodial properties: Focus on in vitro study against Plasmodium falciparum. Journal of Applied Pharmaceutical Science. 2020 May; 2020 May: 142-157en_US
dc.identifier.issn2231-3354
dc.identifier.placeIndiaen_US
dc.identifier.urihttps://imsear.searo.who.int/handle/123456789/210761
dc.languageenen_US
dc.publisherOpen Science Publishers LLPen_US
dc.relation.issuenumber5en_US
dc.relation.volume10en_US
dc.source.urihttps://dx.doi.org//10.7324/JAPS.2020.10519en_US
dc.subjectBioactive compoundsen_US
dc.subjectdrug developmenten_US
dc.subjectantimalarialen_US
dc.subjectmarine natural producten_US
dc.subjectPorifera.en_US
dc.titleMarine sponge compounds with antiplasmodial properties: Focus on in vitro study against Plasmodium falciparumen_US
dc.typeJournal Articleen_US
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