Comparison of Multisystem Inflammatory Syndrome (MIS-C) and Dengue in Hospitalized Children

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dc.contributor.authorRandhawa, Manjinder Singhen_US
dc.contributor.authorJayashree, Muralidharanen_US
dc.contributor.authorAngurana, Suresh Kumaren_US
dc.contributor.authorNallasamy, Karthien_US
dc.contributor.authorMinz, Ranjana W.en_US
dc.contributor.authorKumar, Mahendraen_US
dc.contributor.authorRavikumar, Namitaen_US
dc.contributor.authorAwasthi, Pusprajen_US
dc.contributor.authorGhosh, Arnaben_US
dc.contributor.authorRatho, R. K.en_US
dc.contributor.authorKumar, Rohit Manojen_US
dc.contributor.authorBansal, Arunen_US
dc.date.accessioned2023-08-19T04:53:38Z
dc.date.available2023-08-19T04:53:38Z
dc.date.issued2023-07
dc.description.abstractObjective Multisystem infammatory syndrome (MIS-C) in children is a febrile illness that has overlapping presentation with other locally prevalent illnesses. Clinicolaboratory profle of children admitted with MIS-C and dengue were compared to understand their presentation at the outset. Methods This was a retrospective study of children?12 y admitted with MIS-C (WHO defnition) or laboratory-confrmed dengue between August 2020 and January 2021 at a tertiary center in North India. Results A total of 84 children (MIS-C - 40; dengue - 44) were included. The mean (SD) age [83.5 (39) vs. 91.6 (35) mo] was comparable. Rash (72.5% vs. 22.7%), conjunctival injection (60% vs. 2.3%), oral mucocutaneous changes (27.5% vs. 0) and gallop rhythm (15% vs. 0) were seen more frequently with MIS-C, while petechiae [29.5% vs. 7.5%], myalgia (38.6% vs. 10%), headache (22.7% vs. 2.5%), and hepatomegaly (68.2% vs. 27.5%) were more common with dengue. Children with MIS-C had signifcantly higher C-reactive protein (124 vs. 3.2 mg/L) and interleukin 6 (95.3 vs. 20.7 ng/mL), while those with dengue had higher hemoglobin (12 vs. 10.2 g/dL) lower mean platelet count (26 vs. 140× 109 /L), and greater elevation in aspartate (607 vs. 44 IU/L) and alanine (235.5 vs. 56 IU/L) aminotransferases. The hospital stay was longer with MIS-C; however, PICU stay and mortality were comparable. Conclusion In hospitalized children with acute febrile illness, the presence of mucocutaneous features and highly elevated CRP could distinguish MIS-C from dengue. The presence of petechiae, hepatomegaly, and hemoconcentration may favor a diagnosis of dengue.en_US
dc.identifier.affiliationsPediatric Emergency and Intensive Care Units, Department of Pediatrics, Advanced Pediatrics Center, Postgraduate Institute of Medical Education and Research (PGIMER), Chandigarh 160012, Indiaen_US
dc.identifier.affiliationsDepartment of Immunopathology, Postgraduate Institute of Medical Education and Research (PGIMER), Chandigarh, Indiaen_US
dc.identifier.affiliationsDepartment of Virology, Postgraduate Institute of Medical Education and Research (PGIMER), Chandigarh, Indiaen_US
dc.identifier.affiliationsDepartment of Cardiology, Postgraduate Institute of Medical Education and Research (PGIMER), Chandigarh, Indiaen_US
dc.identifier.citationRandhawa Manjinder Singh, Jayashree Muralidharan, Angurana Suresh Kumar, Nallasamy Karthi, Minz Ranjana W., Kumar Mahendra, Ravikumar Namita, Awasthi Puspraj, Ghosh Arnab, Ratho R. K., Kumar Rohit Manoj, Bansal Arun. Comparison of Multisystem Inflammatory Syndrome (MIS-C) and Dengue in Hospitalized Children. Indian Journal of Pediatrics. 2023 Jul; 90(7): 654–659en_US
dc.identifier.issn0973-7693
dc.identifier.issn0019-5456
dc.identifier.placeIndiaen_US
dc.identifier.urihttps://imsear.searo.who.int/handle/123456789/223758
dc.languageenen_US
dc.publisherDr. K C Chaudhuri Foundationen_US
dc.relation.issuenumber7en_US
dc.relation.volume90en_US
dc.source.urihttps://doi.org/10.1007/s12098-022-04184-2en_US
dc.subjectDengueen_US
dc.subjectMIS-Cen_US
dc.subjectPIMS-TSen_US
dc.subjectCOVID-19en_US
dc.subjectSARS-CoV-2en_US
dc.titleComparison of Multisystem Inflammatory Syndrome (MIS-C) and Dengue in Hospitalized Childrenen_US
dc.typeJournal Articleen_US
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