Pharmacological evaluation of Pachyrrhizus erosus (L) seeds for central nervous system depressant activity.

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dc.contributor.authorAbid, Mohden_US
dc.contributor.authorHrishikeshavan, H Jen_US
dc.contributor.authorAsad, Mohammeden_US
dc.date.accessioned2006-04-21en_US
dc.date.accessioned2009-06-01T05:20:50Z
dc.date.available2006-04-21en_US
dc.date.available2009-06-01T05:20:50Z
dc.date.issued2006-04-21en_US
dc.description.abstractThe research work deals with the screening of ethanol and chloroform extracts of Pachyrrhizus erosus seeds for central nervous system (CNS) depressant activity. The Pachyrrhizus erosus seed is known to contain rotinoids, flavonoids and phenylfuranocoumarin derivatives as chemical components and is reported to have antifungal, antisecretory, insecticides, antibacterial and spasmolytic activity. Since seeds of Pachyrrhizus erosus is used as folk medicine in treatment of insomnia, we made an attempt to study its CNS depressant effect. The different activities studied were potentiation of pentobarbitone-induced sleep, test for locomotor activity, effect on muscle co-ordination, antiaggressive and antianxiety activities. The result of the study reflected that ethanol extract of the seeds (150 mg/kg, p.o) decreased locomotor activity, produced muscle relaxation and showed antianxiety and antiaggressive activity.en_US
dc.description.affiliationKrupanidhi College of Pharmacy, #5, Sarjapur Road, Koramangala, Bangalore 560 034.en_US
dc.identifier.citationAbid M, Hrishikeshavan HJ, Asad M. Pharmacological evaluation of Pachyrrhizus erosus (L) seeds for central nervous system depressant activity. Indian Journal of Physiology and Pharmacology. 2006 Apr-Jun; 50(2): 143-51en_US
dc.identifier.urihttps://imsear.searo.who.int/handle/123456789/106542
dc.language.isoengen_US
dc.source.urihttps://www.ijpp.comen_US
dc.subject.meshAggression --drug effectsen_US
dc.subject.meshAnimalsen_US
dc.subject.meshAnti-Anxiety Agents --pharmacologyen_US
dc.subject.meshCentral Nervous System Depressants --pharmacologyen_US
dc.subject.meshFemaleen_US
dc.subject.meshHypnotics and Sedatives --pharmacologyen_US
dc.subject.meshMaleen_US
dc.subject.meshMaze Learning --drug effectsen_US
dc.subject.meshMiceen_US
dc.subject.meshMotor Activity --drug effectsen_US
dc.subject.meshMuscle Relaxants, Central --pharmacologyen_US
dc.subject.meshPachyrhizus --chemistryen_US
dc.subject.meshPlant Extracts --pharmacologyen_US
dc.subject.meshSeeds --chemistryen_US
dc.titlePharmacological evaluation of Pachyrrhizus erosus (L) seeds for central nervous system depressant activity.en_US
dc.typeJournal Articleen_US
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