Polymorphism of Vitamin D Receptor Gene -Taq1 (RS 731236) Associated With Plasma Vitamin D Group Levels Among Breast Cancer Patients in H. Adam Malik Hospital, Medan

dc.contributor.authorWaraztuty, Ikaen_US
dc.contributor.authorSiregar, Yahwardiahen_US
dc.contributor.authorSiregar, Kamal Basrien_US
dc.contributor.authorWanandi, Septelia Inawatien_US
dc.contributor.authorBetty, Bettyen_US
dc.date.accessioned2020-11-18T10:29:12Z
dc.date.available2020-11-18T10:29:12Z
dc.date.issued2020-02
dc.description.abstractAim Breast cancer was one of the most cancer occurred in women worldwide. Taq 1 polymorphism, a silent SNP,was thought to be genetic risk factor for breast cancer. This study was aimed to understand the relationshipbetween vitamin D receptor gene–Taq 1 (RS 731236) polymorphism and plasma vitamin D level among breastcancer patients in RSU H. Adam Malik Medan. Material and Methods Blood sample was collected from 53 newbreast cancer cases that had not received any chemotherapy. DNA isolation and gene amplification was doneusing PCR then followed with RFLP using Taq 1 restriction enzyme. The level of 25(OH)D was measured usingELISA. Result and Discussion Study results showed TT genotype was 92.5%, TC genotype was 7.5%, CC genotypewas 0 % using Hardy-Winberg Equilibrium (HWE) p=0.77, mean value of vitamin D level in study subject was28.16 ng/ml (CI 95%: 25.71-30.60). Fisher exact test analysis concluded that polymorphism of vitamin D receptorgene-Taq1 associated with plasma vitamin D group levels among breast cancer patients in H. Adam MalikHospital, Medan (p= 0.033) but there was no difference in mean plasma vitamin D levels between genotypegroups of Taq1 (p=0.141). Conclusion Vitamin D receptor gene-Taq1 polymorphism was associated with plasmavitamin D group level and but no significant differences in mean plasma vitamin D levels between genotypegroups of Taq1.en_US
dc.identifier.affiliationsDepartment of Anatomy-Histology, Universitas Syiah Kuala, Aceh, Indonesiaen_US
dc.identifier.affiliationsBiomedical Science Master Program, Faculty of Medicine, Universitas Sumatera Utara, Medan, Indonesiaen_US
dc.identifier.affiliationsDepartment of Biochemistry, Faculty of Medicine, Universitas Sumatera Utara, Medan, Indonesiaen_US
dc.identifier.affiliationsDepartment of Oncology Surgery H. Adam Malik Hospital, Medan, Indonesiaen_US
dc.identifier.affiliationsDepartment of Biochemistry and Molecular Biology, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesiaen_US
dc.identifier.affiliationsDepartement of Pathology Anatomy, Faculty of Medicine, Universitas Sumatera Utara, Medan, Indonesiaen_US
dc.identifier.citationWaraztuty Ika, Siregar Yahwardiah, Siregar Kamal Basri, Wanandi Septelia Inawati, Betty Betty. Polymorphism of Vitamin D Receptor Gene -Taq1 (RS 731236) Associated With Plasma Vitamin D Group Levels Among Breast Cancer Patients in H. Adam Malik Hospital, Medan. Journal of Pharmaceutical and Biomedical Sciences. 2020 Feb; 10(2): 19-25en_US
dc.identifier.issn2230-7885
dc.identifier.placeIndiaen_US
dc.identifier.urihttps://imsear.searo.who.int/handle/123456789/215731
dc.languageenen_US
dc.publisherLawarence Press Pvt. Ltd.en_US
dc.relation.issuenumber2en_US
dc.relation.volume10en_US
dc.source.urihttps://lawarencepress.com/ojs/index.php/JPBMS/article/view/597/pdf_287en_US
dc.subjectPolymorphismen_US
dc.subjectVDR- Taq1en_US
dc.subjectVitamin D levelen_US
dc.subjectBreast Canceren_US
dc.titlePolymorphism of Vitamin D Receptor Gene -Taq1 (RS 731236) Associated With Plasma Vitamin D Group Levels Among Breast Cancer Patients in H. Adam Malik Hospital, Medanen_US
dc.typeJournal Articleen_US
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