Heart rate variability in normotensive subjects with family history of hypertension.
Loading...
Date
2011-07
Journal Title
Journal ISSN
Volume Title
Publisher
Abstract
Hypertension (HT) is a major silent disease affecting young
people because of their hereditary and modern lifestyles. Target organ
damages occur before overt hypertension is diagnosed. Many offspring of
HT parents show early changes in their cardiovascular autonomic functions.
Heart rate variability (HRV) provides a window to understand the cardiac
autonomic balance. This study was designed to quantify and to compare the
HRV among the normotensive young male offspring without history of
parenteral hypertension & diabetic (control group, n=25, age 20.8±2.4, BMI
24.4±3.1) with parenteral history of hypertension & non diabetic (study
group n=25, age 19.7±1.9, 24.05±3.5). Blood pressure, heart rate (HR),
indices of short term HRV during supine rest and quiet standing, HR
variation during timed controlled deep breathing was compared between
the two groups. There were significant difference in low frequency (LF)
power, HF power, total power. LF and HF expressed also in normalized
units at rest and standing. In time domain standard deviation of normal to
normal RR interval (SDNN) at supine rest and standing were significant.
Respiratory sinus arrthymia (RSA), HF in normalized units, deep breathing
difference (BDD) and the ratio of maximum RR to minimum RR were also
significant in the control group than study group. In the present study
there was an increased sympathetic and decreased parasympathetic activity
in the study group. These findings are an early marker of cardiovascular
autonomic impairment in subjects with parenteral history of hypertension.
Description
Keywords
heart rate variability, sympathovagal balance, autonomic nervous system
Citation
Muralikrishnan Krishnan, Balasubramanian Kabali, Rao Badanidiyur Viswanatha. Heart rate variability in normotensive subjects with family history of hypertension. Indian Journal of Physiology and Pharmacology. 2011 Jul-Sept; 55(3): 253-261.