Comparative study of clomiphene citrate versus letrozole as first-line ovulation induction drug in infertile polycystic ovary syndrome women

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dc.contributor.authorSahu, Mahijaen_US
dc.contributor.authorRout, Nihar Ranjanen_US
dc.date.accessioned2020-10-16T08:05:52Z
dc.date.available2020-10-16T08:05:52Z
dc.date.issued2020-07
dc.description.abstractBackground: Polycystic ovary syndrome is the commonest endocrinopathy resulting in anovulatory infertile young women. Clomifene citrate (clomiphene) is a long-standing standard drug for ovulation induction, and is still considered as first line option in PCOS women. However, clomiphene has certain disadvantage letrozole an aromatase inhibitor acts by reducing estrogen production and has no adverse effects on endometrium and cervical mucous. Indian PCOS women have high prevalence of insulin resistance and thus are likely to have high clomiphene resistance. So letrozole could prove to be a good alternative for ovulation induction in such women.Methods: This was a prospective randomized, parallel, comparative clinical trial of two ovulation induction drugs letrozole 5 mg versus clomiphene citrate 100 mg as first-line ovulation induction drug in infertile polycystic ovarian syndrome women. The target population of the study was one hundred infertile women with PCO (taking at least 2 Rotterdam’s parameters). 50 women were allocated to clomifene citrate and 50 were allocated to Letrozole for ovulation induction. Parameters like age, duration of infertility, B MI, ovulation rate, number of follicles, pregnancy rate, endometrial thickness were noted and analyzed.Results: In letrozole group, the ovulation rate, mono-follicular development, mean endometrial thickness and pregnancy rate was better in comparison to clomifene citrate group.Conclusions: The result of this study suggests that letrozole may replace clomiphene as the first line drug for ovulation induction in infertile PCOS women.en_US
dc.identifier.affiliationsDepartment of Obstetrics and Gynecology, Sriram Chandra Bhanj Medical College and Hospital, Cuttack, Odisha, Indiaen_US
dc.identifier.affiliationsDepartment of Obstetrics and Gynecology, Institute of Medical Sciences and SUM Hospital, Bhubaneswar, Odisha, Indiaen_US
dc.identifier.citationSahu Mahija, Rout Nihar Ranjan. Comparative study of clomiphene citrate versus letrozole as first-line ovulation induction drug in infertile polycystic ovary syndrome women. International Journal of Reproduction, Contraception, Obstetrics and Gynecology. 2020 Jul; 9(7): 2948-2952en_US
dc.identifier.issn2320-1770
dc.identifier.issn2320-1789
dc.identifier.placeIndiaen_US
dc.identifier.urihttps://imsear.searo.who.int/handle/123456789/207866
dc.languageenen_US
dc.publisherMedip Academyen_US
dc.relation.issuenumber7en_US
dc.relation.volume9en_US
dc.source.urihttps://dx.doi.org/10.18203/2320-1770.ijrcog20202738en_US
dc.subjectClomifene citrateen_US
dc.subjectLetrozoleen_US
dc.subjectOvulation inductionen_US
dc.subjectPolycystic ovary syndromeen_US
dc.titleComparative study of clomiphene citrate versus letrozole as first-line ovulation induction drug in infertile polycystic ovary syndrome womenen_US
dc.typeJournal Articleen_US
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