Impact of propylthiouracil on quality of life in psoriasis patients.

Simple item page
dc.contributor.authorMalligarjunan, Hemamalini
dc.contributor.authorDayalan, Haripriya
dc.contributor.authorGnanaraj, Pushpa
dc.contributor.authorElango, Tamilselvi
dc.contributor.authorSubramanian, Swapna
dc.date.accessioned2013-03-14T09:52:10Z
dc.date.available2013-03-14T09:52:10Z
dc.date.issued2011-08
dc.description.abstractBackground: Psoriasis greatly impacts the quality of life (QOL) of patients including several dermatological conditions that are listed in the Dermatology Life Quality Index (DLQI). Decrease in psoriatic lesion as measured by Psoriasis Area Severity Index (PASI) score is associated with improvement in QOL. Propylthiouracil (PTU) was found to be clinically efficient in clearing psoriatic lesions. Our objective is to find the extent of improvement in QOL in psoriatic patients treated with PTU. Materials and Methods:Twenty-three psoriatic patients who were taking 300 mg PTU/day were involved in the study. Clinical improvement was assessed by PASI score and QOL was assessed by DLQI questionnaire at baseline, 6 th and 12 th week of PTU treatment. Results: Psoriatic patients before treatment showed significantly increased DLQI score when compared with 6 and 12 weeks of PTU treatment which was found to be decreased significantly (P < 0.001) after PTU treatment. There was a positive correlation between DLQI and PASI score at all three intervals of treatment period at P < 0.001 (r = 0.793, r = 0.834, r = 0.801), respectively. Conclusion: Since PTU was found to improve the QOL of psoriasis patients, this study adds an advantage of using it as treatment option in psoriasis.en_US
dc.identifier.citationMalligarjunan Hemamalini, Dayalan Haripriya, Gnanaraj Pushpa, Elango Tamilselvi, Subramanian Swapna. Impact of propylthiouracil on quality of life in psoriasis patients. Indian Journal of Medical Sciences. 2011 Aug; 65(8) 331-336.en_US
dc.identifier.urihttps://imsear.searo.who.int/handle/123456789/145625
dc.language.isoenen_US
dc.source.urihttps://www.indianjmedsci.org/article.asp?issn=0019-5359;year=2011;volume=65;issue=8;spage=331;epage=336;aulast=Malligarjunanen_US
dc.subjectDermatology life quality indexen_US
dc.subjectpropylthiouracilen_US
dc.subjectpsoriasisen_US
dc.subjectquality of life in psoriasisen_US
dc.subject.meshHumans
dc.subject.meshPatients
dc.subject.meshPropylthiouracil --administration & dosage
dc.subject.meshPropylthiouracil --therapeutic use
dc.subject.meshPsoriasis --drug therapy
dc.subject.meshQuality of Life
dc.titleImpact of propylthiouracil on quality of life in psoriasis patients.en_US
dc.typeArticleen_US
Files
Original bundle
Now showing 1 - 1 of 1
Thumbnail Image
Name:
ijms2011v65n8p331.pdf
Size:
470.62 KB
Format:
Adobe Portable Document Format
Description:
Journal article
Download
License bundle
Now showing 1 - 1 of 1
No Thumbnail Available
Name:
license.txt
Size:
1.71 KB
Format:
Item-specific license agreed upon to submission
Description:
Download
Collections
Indian Journal of Medical Sciences