Beta-adrenoreceptor blockade attenuates heat-induced tachycardia,but not the tolerance to the stress.

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dc.contributor.authorApte, C Ven_US
dc.contributor.authorDikshit, M Ben_US
dc.contributor.authorPrasad, B Aen_US
dc.date.accessioned1992-07-01en_US
dc.date.accessioned2009-06-01T06:00:16Z
dc.date.available1992-07-01en_US
dc.date.available2009-06-01T06:00:16Z
dc.date.issued1992-07-01en_US
dc.description.abstractTen healthy males (age 34 +/- 3 yr 9 SE) underwent 40 min of heat exposure (WD 39.7.C) after 2 hours of ingesting 120 mg of Propranolol (Inderal; ICI), or a placebo, in a random manner, the exposures being about a week apart. That there was no placebo effect was ensured by giving a control run (no medication). In the placebo trials, the end-experiment heart rate had increased by 52%, while after propranolol the increase was only 43%. Regression analysis showed that with the placebo, the HR increased by 22 beats/min/o rise in core (aural) temperature, while with propranolol, the rise (14 beats/min) was significantly lower (P < 0.02). The various heat strain indices viz the Craig's Index, the Body heat storage (Kilocals/m2/hr), and the effective heat storage were also similar for both the treatments. We conclude that beta-adrenoreceptor activity plays a significant role in producing tachycardia of heat exposure in humans, but blocking this activity with propranolol does not affect tolerance to heat stress.en_US
dc.description.affiliationDepartment of Physiology, Armed Forces Medical College, Pune.en_US
dc.identifier.citationApte CV, Dikshit MB, Prasad BA. Beta-adrenoreceptor blockade attenuates heat-induced tachycardia,but not the tolerance to the stress. Indian Journal of Physiology and Pharmacology. 1992 Jul; 36(3): 149-54en_US
dc.identifier.urihttps://imsear.searo.who.int/handle/123456789/107050
dc.language.isoengen_US
dc.source.urihttps://www.ijpp.comen_US
dc.subject.meshAdministration, Oralen_US
dc.subject.meshAdulten_US
dc.subject.meshBlood Pressure --drug effectsen_US
dc.subject.meshBody Temperature --drug effectsen_US
dc.subject.meshHeart Rate --drug effectsen_US
dc.subject.meshHot Temperature --adverse effectsen_US
dc.subject.meshHumansen_US
dc.subject.meshMaleen_US
dc.subject.meshPropranolol --administration & dosageen_US
dc.subject.meshReceptors, Adrenergic, beta --drug effectsen_US
dc.subject.meshStress, Physiological --physiopathologyen_US
dc.subject.meshTachycardia --etiologyen_US
dc.titleBeta-adrenoreceptor blockade attenuates heat-induced tachycardia,but not the tolerance to the stress.en_US
dc.typeClinical Trialen_US
dc.typeJournal Articleen_US
dc.typeRandomized Controlled Trialen_US
dc.typeResearch Support, Non-U.S. Gov'ten_US
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