Treatment of patients with haemophilia and inhibitory antibodies.

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dc.contributor.authorGiangrande, P L Fen_US
dc.date.accessioned2003-08-27en_US
dc.date.accessioned2009-05-30T11:16:49Z
dc.date.available2003-08-27en_US
dc.date.available2009-05-30T11:16:49Z
dc.date.issued2003-08-27en_US
dc.description26 references.en_US
dc.description.abstractThe development of inhibitory antibodies is a complication which arise in approximately 10% of patients with haemophilia A. The underlying genetic mutation is the single most important predisposing cause, although other risk factors have been identified. Periodic screening for inhibitors is a vital aspect of haemophilia care. The consequences of inhibitor development are very significant in terms of morbidity and cost. Several agents are now available for control of bleeding, but these are often very expensive. The most useful agents include recombinant activated factor VII, prothrombin complex concentrates and porcine factor VIII. It is possible to suppress antibody production with immune tolerance, which is successful in approximately 85% of cases and relapse is rare.en_US
dc.description.affiliationOxford Haemophilia Centre and Thrombosis Unit, Churchill Hospital, UK. paul.giangrande@ndm.ox.ac.uken_US
dc.identifier.citationGiangrande PL. Treatment of patients with haemophilia and inhibitory antibodies. Indian Journal of Pediatrics. 2003 Aug; 70(8): 655-9en_US
dc.identifier.urihttps://imsear.searo.who.int/handle/123456789/79512
dc.language.isoengen_US
dc.source.urihttps://medind.nic.in/icb/icbai.shtmlen_US
dc.subject.meshBlood Coagulation Factor Inhibitors --blooden_US
dc.subject.meshBlood Coagulation Factors --therapeutic useen_US
dc.subject.meshChilden_US
dc.subject.meshChild, Preschoolen_US
dc.subject.meshFactor VIII --therapeutic useen_US
dc.subject.meshFactor VIIa --therapeutic useen_US
dc.subject.meshGenetic Predisposition to Diseaseen_US
dc.subject.meshHemophilia A --blooden_US
dc.subject.meshHumansen_US
dc.subject.meshImmune Tolerance --drug effectsen_US
dc.subject.meshInfanten_US
dc.titleTreatment of patients with haemophilia and inhibitory antibodies.en_US
dc.typeJournal Articleen_US
dc.typeReviewen_US
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