Carnitine supplementation in diphtheria.

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dc.contributor.authorRamos, A Cen_US
dc.contributor.authorBarrucand, Len_US
dc.contributor.authorElias, P Ren_US
dc.contributor.authorPimentel, A Men_US
dc.contributor.authorPires, V Ren_US
dc.date.accessioned1992-12-01en_US
dc.date.accessioned2009-05-27T06:13:22Z
dc.date.available1992-12-01en_US
dc.date.available2009-05-27T06:13:22Z
dc.date.issued1992-12-01en_US
dc.description.abstractWe studied the effect of carnitine supplementation in patients with diphtheria. Six hundred and twenty five children of diphtheria received either DL-carnitine (100 mg/kg/day in two divided doses orally for four days), or no carnitine, in addition to the routine treatment for diphtheria. The patients receiving carnitine (n = 327) and controls (n = 298) were matched for age, sex, duration of symptoms, grade of toxemia and immunization status. Patients receiving carnitine showed a significant reduction in incidence of myocarditis as compared to controls (p = 0.001). Cases with myocarditis receiving carnitine therapy showed a significant reduction in mortality as compared to controls (p < 0.001). In view of a significant decline in incidence and mortality of myocarditis in cases of diphtheria, we recommended that all cases with diphtheria should receive carnitine supplementation.en_US
dc.description.affiliationDepartment of Pediatrics, UFRJ, Rio de Janeiro, Brasil.en_US
dc.identifier.citationRamos AC, Barrucand L, Elias PR, Pimentel AM, Pires VR. Carnitine supplementation in diphtheria. Indian Pediatrics. 1992 Dec; 29(12): 1501-5en_US
dc.identifier.urihttps://imsear.searo.who.int/handle/123456789/15574
dc.language.isoengen_US
dc.source.urihttps://indianpediatrics.neten_US
dc.subject.meshBrazil --epidemiologyen_US
dc.subject.meshCarnitine --therapeutic useen_US
dc.subject.meshChilden_US
dc.subject.meshChild, Preschoolen_US
dc.subject.meshDiphtheria --complicationsen_US
dc.subject.meshFemaleen_US
dc.subject.meshHumansen_US
dc.subject.meshIncidenceen_US
dc.subject.meshInfanten_US
dc.subject.meshMaleen_US
dc.subject.meshMyocarditis --etiologyen_US
dc.titleCarnitine supplementation in diphtheria.en_US
dc.typeClinical Trialen_US
dc.typeJournal Articleen_US
dc.typeRandomized Controlled Trialen_US
dc.typeResearch Support, Non-U.S. Gov'ten_US
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