Effect of macrocomponents of food on the pharmacokinetics of a long acting preparation of anhydrous theophylline.
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1993-10-01
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Abstract
In a single dose crossover study, the effect of macrocomponents of food on the pharmacokinetics of a long acting preparation of anhydrous theophylline was investigated. Compared to fasting subjects, carbohydrate and fat rich diet caused an enhancement of absorption half life and a lower Cmax with a delayed tmax and elimination of the bronchodilator. Protein coadministration decreased AUCO-OC of the drug without significantly altering its absorption or elimination kinetics.
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Sangeeta , Raina RK, Bano G. Effect of macrocomponents of food on the pharmacokinetics of a long acting preparation of anhydrous theophylline. Indian Journal of Physiology and Pharmacology. 1993 Oct; 37(4): 303-7