Evaluation of long-term results of two schedules of treatment for toxic multinodular goitre with radioiodine therapy (I 131).

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dc.contributor.authorKhanna, C Men_US
dc.contributor.authorMagdum, Men_US
dc.contributor.authorRavishankar, Len_US
dc.contributor.authorDham, D Nen_US
dc.contributor.authorChugh, Pen_US
dc.date.accessioned1996-02-01en_US
dc.date.accessioned2009-05-31T01:32:37Z
dc.date.available1996-02-01en_US
dc.date.available2009-05-31T01:32:37Z
dc.date.issued1996-02-01en_US
dc.description.abstractResults of the long term effects of two schedules of radioine therapy (I131) in 130 toxic multinodular goitre patients were evaluated. Seventy five patients (group I) were treated with low doses and 55 patients (group II) with calculated high doses adjusted for thyroid weight (0.5-1 mu ci/g) and radioiodine uptake. Follow up (mean +/- SEM) was 4.5 +/- 0.4 years and 4.8 +/- 0.6 years respectively (p > 0.1). At the end of followup hyperthyroidism was successfully reversed in 87% (Group I) and 82% (Group II). In group I hypothyroidism was present in 5% of patients while it was 12.5% in group II patients. The total dose per gram of thyroid tissue was not significantly different in both the groups (0.058 mu ci +/- 0.0054 VS 0.073 +/- 0.0054 ci/g.) However in group II the number of I131 administration was significantly lower (1.5 +/- 0.2) than in group I (3.2 +/- 0.4) and the percentage of patients who were adequately treated in Group II with single dose was more as compared in group I (62% in group II versus 49% in group I) Hypothyroidism was reached in a shorter time after treatment in group II (median time 0.8 year in group II Vs 1.1 yrs in group I). Patients with positive thyroid antibodies showed a significant earlier development of hypothyroidism within six months. It is concluded that radioiodine is an effective treatment for toxic multinodular goitre with a significant low incidence of post therapy hypothyroidism in patients treated with low doses as compared to higher doses of radioiodine therapy.en_US
dc.description.affiliationDept of Endocrinology, Institute of Nuclear Medicine & Allied Sciences, Delhi.en_US
dc.identifier.citationKhanna CM, Magdum M, Ravishankar L, Dham DN, Chugh P. Evaluation of long-term results of two schedules of treatment for toxic multinodular goitre with radioiodine therapy (I 131). Journal of the Association of Physicians of India. 1996 Feb; 44(2): 102-5en_US
dc.identifier.urihttps://imsear.searo.who.int/handle/123456789/92265
dc.language.isoengen_US
dc.source.urihttps://www.japi.orgen_US
dc.subject.meshAdulten_US
dc.subject.meshDose-Response Relationship, Radiationen_US
dc.subject.meshFemaleen_US
dc.subject.meshFollow-Up Studiesen_US
dc.subject.meshGoiter, Nodular --blooden_US
dc.subject.meshHumansen_US
dc.subject.meshIodine Radioisotopes --therapeutic useen_US
dc.subject.meshMaleen_US
dc.subject.meshMiddle Ageden_US
dc.subject.meshRemission Inductionen_US
dc.subject.meshThyroid Gland --radiation effectsen_US
dc.titleEvaluation of long-term results of two schedules of treatment for toxic multinodular goitre with radioiodine therapy (I 131).en_US
dc.typeClinical Trialen_US
dc.typeComparative Studyen_US
dc.typeJournal Articleen_US
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