Lynch syndrome: An unusal case of familial cancer unearthed
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Date
2022-06
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Volume Title
Publisher
Wolters Kluwer - Medknow
Abstract
Lynch syndrome or hereditary nonpolyposis colorectal cancer (HNPCC) is a type of inherited cancer syndrome with a genetic predisposition to different types of cancer. There is an increased predisposition to cancers in the endometrium, colon, stomach, ovary, uterus, skin, kidney, and brain in patients of Lynch syndrome. We are reporting a 48-year-old male who presented with a pea-sized growth in his left arm which was found to be sebaceoma on histopathology. On further detailed history, examination, and genetic study, it was proved to be a familial case of Lynch syndrome. The case is being reported to stress the importance of knowledge about clinical manifestation, associated neoplasms, and molecular genetic profile of Lynch syndrome which will enable physicians and pathologists to provide highly targeted surveillance and management for patients with high cancer risk.
Description
Keywords
Familial cancer, genetic testing, Lynch syndrome, sebaceoma, sebaceous neoplasms
Citation
Dhar S, Mannan AU, Singh J J, Dhar S, Pradhan S.. Lynch syndrome: An unusal case of familial cancer unearthed. Indian Journal of Pathology & Microbiology. 2022 Jun; 65(2): 465-467