The role of intensity-modulated radiotherapy in head and neck cancer.

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dc.contributor.authorBhide, S A
dc.contributor.authorKazi, R
dc.contributor.authorNewbold, K
dc.contributor.authorHarrington, K J
dc.contributor.authorNutting, C M
dc.date.accessioned2013-01-15T09:11:02Z
dc.date.available2013-01-15T09:11:02Z
dc.date.issued2010-07
dc.description.abstractIntensity-modulated radiotherapy (IMRT) has been a significant technological advance in the field of radiotherapy in recent years. IMRT allows sparing of normal tissue while delivering radical radiation doses to the target volumes. The role of IMRT for parotid salivary gland sparing in head and neck cancer is well established. The utility of IMRT for pharyngeal constrictor muscle and cochlear sparing requires investigation in clinical trials. The current evidence supporting the use of IMRT in various head and neck subsites has been summarized. Sparing of organs at risk allows for dose-escalation to the target volumes, taking advantage of the steep dose-response relationship for squamous cell carcinomas to improve treatment outcomes in advanced head and neck cancers. However, dose-escalation could result in increased radiation toxicity (acute and late), which has to be studied in detail. The future of IMRT in head and neck cancers lies in exploring the use of biological imaging for dose-escalation using targeted dose painting.en_US
dc.identifier.citationBhide S A, Kazi R, Newbold K, Harrington K J, Nutting C M. The role of intensity-modulated radiotherapy in head and neck cancer. Indian Journal of Cancer. 2010 Jul-Sept; 47(3): 267-273.en_US
dc.identifier.urihttps://imsear.searo.who.int/handle/123456789/144349
dc.language.isoenen_US
dc.source.urihttps://www.indianjcancer.com/article.asp?issn=0019-509X;year=2010;volume=47;issue=3;spage=267;epage=273;aulast=Bhideen_US
dc.subjectIntensity-modulated radiotherapyen_US
dc.subjecthead and neck canceren_US
dc.subject.meshCarcinoma, Squamous Cell --diagnosis
dc.subject.meshCarcinoma, Squamous Cell --pathology
dc.subject.meshCarcinoma, Squamous Cell --radiotherapy
dc.subject.meshClinical Trials as Topic
dc.subject.meshCochlea --pathology
dc.subject.meshCochlea --radiation effects
dc.subject.meshDose-Response Relationship, Radiation
dc.subject.meshHead and Neck Neoplasms --diagnosis
dc.subject.meshHead and Neck Neoplasms --pathology
dc.subject.meshHead and Neck Neoplasms --radiotherapy
dc.subject.meshHumans
dc.subject.meshPharyngeal Muscles --pathology
dc.subject.meshPharyngeal Muscles --radiation effects
dc.subject.meshRadiation Injuries --prevention & control
dc.subject.meshRadiation Monitoring
dc.subject.meshRadiation Oncology --methods
dc.subject.meshRadiation Oncology --trends
dc.subject.meshRadiotherapy Dosage
dc.subject.meshRadiotherapy, Conformal
dc.titleThe role of intensity-modulated radiotherapy in head and neck cancer.en_US
dc.typeArticleen_US
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