Antibiotic sensitivity pattern of causative organisms of neonatal septicemia in an urban hospital of Bangladesh.

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dc.contributor.authorMonjur, Forhad
dc.contributor.authorRizwan, Farhana
dc.contributor.authorAsaduzzaman, Muhammad
dc.contributor.authorNasrin, Nishat
dc.contributor.authorGhosh, Nobo Krishna
dc.contributor.authorApu, Apurba Sarker
dc.contributor.authorHaque, Fazlul
dc.date.accessioned2013-03-11T05:51:35Z
dc.date.available2013-03-11T05:51:35Z
dc.date.issued2010-06
dc.description.abstractBackground: The information of the sensitivity pattern of the causative organisms is very important for effective control of septicemia in neonates. OBJECTIVE: To determine the proportion and profile of pathogenic bacteria in the blood cultures of the neonates with clinically suspected septicemia and their susceptibility pattern to antimicrobial agents for developing a unified antibiotic treatment protocol. Materials and Methods: A cross-sectional retrospective study was conducted over a period of 3 year and 4 months (39 months). The study included 1000 patients admitted in the selected hospital in Bangladesh. Blood samples for culture were taken aseptically before starting antibiotic therapy. Microorganisms were isolated and identified by standard microbiological processes which include colony morphology, Gram stain, and biochemical profiles. Antimicrobial sensitivity patterns were performed by Kirby-Bauer's disc diffusion method against imipenem, ciprofloxacin, ceftazidime, chloramphenicol, netilmicin, gentamicin, ceftriaxone, aztreonam, cefotaxime, cephalexin, and ampicillin. Results: Among the patients, 633 (63.3%) were males and 367 (36.7%) were females. Blood cultures were found positive in 194 (19.4%) neonates. The organisms isolated were Pseudomonas spp. (31.4%), Klebsiella pneumoniae (23.2%), Staphylococcus aureus (12.4%), Escherichia coli (7.2%), Acinatobactor (5.7%), Gram-negative Bacilli (4.1%), Flavobacterium spp. (3.6%), Serratia spp. (5.7%), Citrobacter fruendi (3.1%), Streptococcus species (2.6%), and Enterobacter spp. (1.0%). A majority of the bacterial isolates in neonatal sepsis were found sensitive to imipenem (91.8%) and ciprofloxacin (57.2%) and resistant to commonly used antibiotics, eg. ampicillin (96.4%) and cephalexin (89.2%). Conclusion : The problem can be mitigated by careful selection and prudent use of available antibiotics.en_US
dc.identifier.citationMonjur Forhad, Rizwan Farhana, Asaduzzaman Muhammad, Nasrin Nishat, Ghosh Nobo Krishna, Apu Apurba Sarker, Haque Fazlul. Antibiotic sensitivity pattern of causative organisms of neonatal septicemia in an urban hospital of Bangladesh. Indian Journal of Medical Sciences. 2010 June; 64(6) 265-271.en_US
dc.identifier.urihttps://imsear.searo.who.int/handle/123456789/145539
dc.language.isoenen_US
dc.source.urihttps://www.indianjmedsci.org/article.asp?issn=0019-5359;year=2010;volume=64;issue=6;spage=265;epage=271;aulast=Monjuren_US
dc.subjectAntibioticsen_US
dc.subjectbacterial pathogenen_US
dc.subjectblood cultureen_US
dc.subjectneonatal septicemiaen_US
dc.subjectsensitivityen_US
dc.subject.meshAnti-Bacterial Agents --pharmacology
dc.subject.meshAnti-Bacterial Agents --therapeutic use
dc.subject.meshBacteria --pathogenicity
dc.subject.meshBangladesh --epidemiology
dc.subject.meshBlood --microbiology
dc.subject.meshHospitals, Urban
dc.subject.meshHumans
dc.subject.meshInfant, Newborn
dc.subject.meshInfant, Newborn, Diseases --blood
dc.subject.meshInfant, Newborn, Diseases --drug therapy
dc.subject.meshInfant, Newborn, Diseases --epidemiology
dc.subject.meshInfant, Newborn, Diseases --etiology
dc.subject.meshMicrobial Sensitivity Tests --methods
dc.subject.meshSepsis --blood
dc.subject.meshSepsis --drug therapy
dc.subject.meshSepsis --epidemiology
dc.subject.meshSepsis --etiology
dc.titleAntibiotic sensitivity pattern of causative organisms of neonatal septicemia in an urban hospital of Bangladesh.en_US
dc.typeArticleen_US
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