Convulsions with propofol: a rare adverse event.

Simple item page
dc.contributor.authorGarg, Ren_US
dc.contributor.authorDehran, Men_US
dc.date.accessioned2009-01-27en_US
dc.date.accessioned2009-06-02T11:07:53Z
dc.date.available2009-01-27en_US
dc.date.available2009-06-02T11:07:53Z
dc.date.issued2009-01-27en_US
dc.description.abstractWe present a rare but potentially harmful adverse reaction of propofol. A 50-year-old patient was posted for laparoscopic cholecystectomy, developed generalized convulsions after few seconds of propofol administration at anesthesia induction. Convulsions subsided with intravenous administrations of thiopentone and midazolam. Patient remained hemodynamically stable and surgery was uneventful. Blood sugar, serum electrolytes and arterial blood gas analysis were normal. Postoperatively, there was no evidence of postictal phase, serum electrolytes and postoperative computerized tomographic scanning of the head were normal. Patient had uneventful recovery. The administration of propofol has been associated with abnormal movements collectively termed as seizure-like phenomenon. Despite the claims that propofol may have proconvalsant activity, there is significant amount of evidence to the contrary also. The pathophysiological mechanisms behind the neuroexcitatory symptoms with propofol are unknown. Propofol alters the conscious state, the transition from the conscious state to anesthesia or vice versa may be a particularly vulnerable period and may be prolonged after the end of propofol administration.en_US
dc.description.affiliationDepartment of Anesthesiology and Intensive Care, All India Institute of Medical Sciences, Ansari Nagar, New Delhi -110 029, India. drrgarg@hotmail.comen_US
dc.identifier.citationGarg R, Dehran M. Convulsions with propofol: a rare adverse event. Journal of Postgraduate Medicine. 2009 Jan-Mar; 55(1): 69-71en_US
dc.identifier.urihttps://imsear.searo.who.int/handle/123456789/116003
dc.language.isoengen_US
dc.source.urihttps://www.jpgmonline.comen_US
dc.subject.meshAnesthesia, Intravenous --adverse effectsen_US
dc.subject.meshHumansen_US
dc.subject.meshMaleen_US
dc.subject.meshMidazolam --therapeutic useen_US
dc.subject.meshMiddle Ageden_US
dc.subject.meshPropofol --adverse effectsen_US
dc.subject.meshSeizures --chemically induceden_US
dc.subject.meshThiopental --therapeutic useen_US
dc.titleConvulsions with propofol: a rare adverse event.en_US
dc.typeCase Reportsen_US
dc.typeJournal Articleen_US
Files
License bundle
Now showing 1 - 1 of 1
No Thumbnail Available
Name:
license.txt
Size:
1.79 KB
Format:
Plain Text
Description:
Download
Collections
Journal of Postgraduate Medicine