Evaluation of the histopathologic status of rectal adenocarcinoma and its regional lymph nodes after neoadjuvant therapy, and its relation to the duration of disease-free survival

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dc.contributor.authorKarimi, Fen_US
dc.contributor.authorTabriz, HMen_US
dc.contributor.authorAmoli, HAen_US
dc.contributor.authorNazar, Een_US
dc.contributor.authorVaezi, AA.en_US
dc.date.accessioned2023-08-10T07:32:19Z
dc.date.available2023-08-10T07:32:19Z
dc.date.issued2022-03
dc.description.abstractIntroduction: Colorectal cancer is one of the most common malignant tumors and has a relatively poor prognosis. Lymph node involvement is considered the most important prognostic factor. Materials and Methods: During a retrospective cohort study, 132 patients with locally advanced rectal cancer who underwent neoadjuvant chemoradiotherapy followed by surgery for resectable rectal cancer from 2010 to 2015 in Sina hospital were reviewed. Results: Multivariable analysis was performed and shown the clinical stage was not a representative factor for disease-free survival (P = 0.187), but Dworak Tumor Regression Grading were significantly associated with higher disease-free survival (P = 0.000) in stage II and stage III. The total number of retrieved lymph nodes and involved lymph nodes in the same clinical stage were statistically associated with higher mean disease-free survival in patients (P = 0.000 in both conditions). Conclusion: In the same clinical stage, increasing the Dworak Tumor Regression Grading reduced the risk of rectal cancer recurrence. Increasing total number of retrieved lymph nodes and involved lymph nodes, 2.14 times and 3.87 times increased the risk of recurrence, respectively.en_US
dc.identifier.affiliationsDepartment of Pathology, Alborz University of Medical Sciences, Karaj, Iranen_US
dc.identifier.affiliationsDepartment of Pathology, Tehran University of Medical Sciences, Tehran, Iranen_US
dc.identifier.affiliationsDepartment of Surgery, Tehran University of Medical sciences, Tehran, Iranen_US
dc.identifier.affiliationsDepartment of Internal Medicine, Alborz University of Medical Sciences, Karaj, Iranen_US
dc.identifier.citationKarimi F, Tabriz HM, Amoli HA, Nazar E, Vaezi AA.. Evaluation of the histopathologic status of rectal adenocarcinoma and its regional lymph nodes after neoadjuvant therapy, and its relation to the duration of disease-free survival. Indian Journal of Pathology & Microbiology. 2022 Mar; 65(1): 49-54en_US
dc.identifier.issn0377-4929
dc.identifier.issn0974-5130
dc.identifier.placeIndiaen_US
dc.identifier.urihttps://imsear.searo.who.int/handle/123456789/223258
dc.languageenen_US
dc.publisherWolters Kluwer - Medknowen_US
dc.relation.issuenumber1en_US
dc.relation.volume65en_US
dc.source.urihttps://doi.org/10.4103/IJPM.IJPM_1331_20en_US
dc.subjectDwoark tumor regression gradingen_US
dc.subjectlymph node statusen_US
dc.subjectrectal carcinomaen_US
dc.titleEvaluation of the histopathologic status of rectal adenocarcinoma and its regional lymph nodes after neoadjuvant therapy, and its relation to the duration of disease-free survivalen_US
dc.typeJournal Articleen_US
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