Clinico-immunological profile in juvenile rheumatoid arthritis--an Indian experience.

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dc.contributor.authorSeth, Ven_US
dc.contributor.authorKabra, S Ken_US
dc.contributor.authorSemwal, O Pen_US
dc.contributor.authorJain, Yen_US
dc.date.accessioned1996-05-01en_US
dc.date.accessioned2009-05-30T16:02:49Z
dc.date.available1996-05-01en_US
dc.date.available2009-05-30T16:02:49Z
dc.date.issued1996-05-01en_US
dc.description.abstractFrom a Pediatric Rheumatology Clinic 361 children diagnosed as juvenile rheumatoid arthritis (JRA) according to American Rheumatism Association-JRA criteria were studied retrospectively for their clinico-immunological profile. The mean age of onset in systemic, pauciarticular and polyarticular onset, JRA subtypes were 5.2, 6.8 and 7.2 years respectively. There was male preponderance in systemic and pauciarticular JRA. In seropositive polyarticular JRA, girls outnumbered boys. The frequency of occurrence of systemic, pauciarticular and polyarticular disease was 87 (24%), 108 (30%) and 166 (46%) respectively. The systemic onset disease was dominated by extra-articular manifestations in terms of fever (100%), rash (57%), hepatomegaly (51%) and lymphadenopathy (25%). The pauci- and polyarticular illnesses were commonly dominated by joint involvement, morning stiffness, and in few patients, by extra-articular manifestations also. The joints were involved symmetrically. Most commonly involved joints in order of decreasing frequency were knee, ankle, wrist and elbow in all the subtypes. Anemia and leucocytosis were observed in majority with higher frequency in systemic onset JRA. The rheumatoid factor (RF) was present in 15% of polyarticular JRA. RF was also present in 7 and 9% of patients with pauciarticular and systemic subtypes respectively. The antinuclear antibody was positive in only 3 out of 66 patients in whom the test was carried out. The demographic profile and trends in clinical features were similar to the studies reported on caucasian population with difference in the actual frequency of various clinical features.en_US
dc.description.affiliationDepartment of Pediatrics, All India Institute of Medical Sciences, Ansari Nagar, New Delhi.en_US
dc.identifier.citationSeth V, Kabra SK, Semwal OP, Jain Y. Clinico-immunological profile in juvenile rheumatoid arthritis--an Indian experience. Indian Journal of Pediatrics. 1996 May-Jun; 63(3): 293-300en_US
dc.identifier.urihttps://imsear.searo.who.int/handle/123456789/84196
dc.language.isoengen_US
dc.source.urihttps://medind.nic.in/icb/icbai.shtmlen_US
dc.subject.meshAdolescenten_US
dc.subject.meshAge Distributionen_US
dc.subject.meshAge of Onseten_US
dc.subject.meshArthritis, Juvenile Rheumatoid --classificationen_US
dc.subject.meshChilden_US
dc.subject.meshChild, Preschoolen_US
dc.subject.meshFemaleen_US
dc.subject.meshHumansen_US
dc.subject.meshIndia --epidemiologyen_US
dc.subject.meshMaleen_US
dc.subject.meshPrevalenceen_US
dc.subject.meshRetrospective Studiesen_US
dc.subject.meshRisk Factorsen_US
dc.subject.meshSex Distributionen_US
dc.titleClinico-immunological profile in juvenile rheumatoid arthritis--an Indian experience.en_US
dc.typeComparative Studyen_US
dc.typeJournal Articleen_US
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