Tryptophan and tyrosine catabolic pattern in neuropsychiatric disorders.

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dc.contributor.authorRavikumar, Aen_US
dc.contributor.authorDeepadevi, K Ven_US
dc.contributor.authorArun, Pen_US
dc.contributor.authorManojkumar, Ven_US
dc.contributor.authorKurup, P Aen_US
dc.date.accessioned2000-09-12en_US
dc.date.accessioned2009-06-03T12:16:38Z
dc.date.available2000-09-12en_US
dc.date.available2009-06-03T12:16:38Z
dc.date.issued2000-09-12en_US
dc.description.abstractCatabolism of tryptophan and tyrosine in relation to the isoprenoid pathway was studied in neurological and psychiatric disorders. The concentration of trytophan, quinolinic acid, kynurenic acid, serotonin and 5-hydroxyindoleacetic acid was found to be higher in the plasma of patients with all these disorders; while that of tyrosine, dopamine, epinephrine and norepinephrine was lower. There was increase in free fatty acids and decrease in albumin (factors modulating tryptophan transport) in the plasma of these patients. Concentration of digoxin, a modulator of amino acid transport, and the activity of HMG CoA reductase, which synthesizes digoxin, were higher in these patients; while RBC membrane Na+-K+ ATPase activity showed a decrease. Concentration of plasma ubiquinone (part of which is synthesised from tyrosine) and magnesium was also lower in these patients. No morphine could be detected in the plasma of these patients except in MS. On the other hand, strychnine and nicotine were detectable. These results indicate hypercatabolism of tryptophan and hypocatabolism of tyrosine in these disorders, which could be a consequence of the modulating effect of hypothalamic digoxin on amino acid transport.en_US
dc.description.affiliationDepartment of Neurology, Medical College, Trivandrum, and Metabolic Disorders Research Centre, Puliyarakonam, Trivandrum, India.en_US
dc.identifier.citationRavikumar A, Deepadevi KV, Arun P, Manojkumar V, Kurup PA. Tryptophan and tyrosine catabolic pattern in neuropsychiatric disorders. Neurology India. 2000 Sep; 48(3): 231-8en_US
dc.identifier.urihttps://imsear.searo.who.int/handle/123456789/121446
dc.language.isoengen_US
dc.source.urihttps://neurologyindia.comen_US
dc.subject.meshAdulten_US
dc.subject.meshBiogenic Monoamines --blooden_US
dc.subject.meshBrain Diseases --blooden_US
dc.subject.meshBrain Neoplasms --blooden_US
dc.subject.meshDigoxin --analysisen_US
dc.subject.meshEpilepsy, Generalized --blooden_US
dc.subject.meshErythrocytes --chemistryen_US
dc.subject.meshFatty Acids, Nonesterified --blooden_US
dc.subject.meshFemaleen_US
dc.subject.meshGlioma --blooden_US
dc.subject.meshGlycine Agents --blooden_US
dc.subject.meshHumansen_US
dc.subject.meshHydroxymethylglutaryl CoA Reductases --blooden_US
dc.subject.meshKynurenic Acid --blooden_US
dc.subject.meshMagnesium --analysisen_US
dc.subject.meshMaleen_US
dc.subject.meshMicrovascular Angina --blooden_US
dc.subject.meshMiddle Ageden_US
dc.subject.meshMorphine --blooden_US
dc.subject.meshNarcotics --blooden_US
dc.subject.meshNicotine --blooden_US
dc.subject.meshNicotinic Agonists --blooden_US
dc.subject.meshParkinson Disease --blooden_US
dc.subject.meshQuinolinic Acid --blooden_US
dc.subject.meshSchizophrenia --blooden_US
dc.subject.meshSerum Albuminen_US
dc.subject.meshSodium-Potassium-Exchanging ATPase --analysisen_US
dc.subject.meshStrychnine --blooden_US
dc.subject.meshTryptophan --blooden_US
dc.subject.meshTyrosine --blooden_US
dc.subject.meshUbiquinone --analysisen_US
dc.titleTryptophan and tyrosine catabolic pattern in neuropsychiatric disorders.en_US
dc.typeJournal Articleen_US
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