Incidence of Nelson's syndrome and residual adrenocortical function in patients of Cushing's disease after bilateral adrenalectomy.

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dc.contributor.authorMisra, Den_US
dc.contributor.authorKapur, M Men_US
dc.contributor.authorGupta, D Ken_US
dc.date.accessioned1994-04-01en_US
dc.date.accessioned2009-05-30T21:41:58Z
dc.date.available1994-04-01en_US
dc.date.available2009-05-30T21:41:58Z
dc.date.issued1994-04-01en_US
dc.description.abstractEighteen patients of Cushing's Disease, who had undergone bilateral "total" adrenalectomy 2 to 10 years back, were evaluated for residual adrenocortical function and for any evidence of Nelson's Syndrome. Surprisingly, all patients were discovered to have measurable plasma cortisol, albeit in the subnormal range. The standard criteria for accepting "completeness of adrenalectomy" were fulfilled in 16 patients. It was possible to wean one patient off replacement therapy. Thus, the dose of replacement steroids needs to be regulated according to the blood steroid levels in order to avoid unnecessary hypercortisolism. Radiological evidence of pituitary tumor diagnosed Nelson's Syndrome in 2 patients. Nelson's Syndrome was further suspected in 8 others who showed pigmentation. One of these had an enlarged sella and an erosion of the dorsum sellae, but had a normal CT scan. Another patient had evidence of incidental pituitary pathology (incidentaloma) which resolved spontaneously. Contrast enhanced CT scans of the sella are necessary for early detection of Nelson's Syndrome.en_US
dc.identifier.citationMisra D, Kapur MM, Gupta DK. Incidence of Nelson's syndrome and residual adrenocortical function in patients of Cushing's disease after bilateral adrenalectomy. Journal of the Association of Physicians of India. 1994 Apr; 42(4): 304-5en_US
dc.identifier.urihttps://imsear.searo.who.int/handle/123456789/88856
dc.language.isoengen_US
dc.source.urihttps://www.japi.orgen_US
dc.subject.meshAdenoma --blooden_US
dc.subject.meshAdolescenten_US
dc.subject.meshAdrenal Cortex Function Testsen_US
dc.subject.meshAdrenalectomyen_US
dc.subject.meshAdrenocorticotropic Hormone --diagnostic useen_US
dc.subject.meshAdulten_US
dc.subject.meshCushing Syndrome --blooden_US
dc.subject.meshFemaleen_US
dc.subject.meshHumansen_US
dc.subject.meshHydrocortisone --blooden_US
dc.subject.meshMaleen_US
dc.subject.meshNelson Syndrome --blooden_US
dc.subject.meshPituitary Neoplasms --blooden_US
dc.subject.meshPostoperative Complications --blooden_US
dc.subject.meshRetrospective Studiesen_US
dc.titleIncidence of Nelson's syndrome and residual adrenocortical function in patients of Cushing's disease after bilateral adrenalectomy.en_US
dc.typeJournal Articleen_US
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