How sustained is sustained viral response in patients with hepatitis C virus infection.

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dc.contributor.authorSood, Ajit
dc.contributor.authorMidha, Vandana
dc.contributor.authorMehta, Varun
dc.contributor.authorSharma, Sarit
dc.contributor.authorMittal, Rasham
dc.contributor.authorThara, Amandeep
dc.contributor.authorSood, Neena
dc.contributor.authorKaur, Amarjeet
dc.date.accessioned2012-09-14T03:53:45Z
dc.date.available2012-09-14T03:53:45Z
dc.date.issued2010-05
dc.description.abstractBackground Sustained virological response (SVR) is achieved in a high proportion of patientswith chronic hepatitis C infection, particularly those with genotype 2 or 3 HCV infection. However, data on long-term durability of virological response in patients who achieve SVR are limited. Aim To evaluate the long-term durability of virological response in patients who have achieved SVR with interferon-based combination therapy. Methods One hundred patients with chronic HCV infection who had obtained SVR after IFN and ribavirin combination therapy were followed up for up to 8 years with annual HCV RNA testing. Results During a followed up of 6 months to 8 years, 8 of 100 patients with initial SVR developed late relapse of HCV infection. Relapse was more common in patients who had cirrhosis (5/28 [18%] vs. (3/72 [4%] with no cirrhosis; p=0.037). Conclusion SVR is durable in most patients, but some patients do have late relapse; long term follow up may be particularly important in a subset of patients with HCV infection who have liver cirrhosis.en_US
dc.identifier.citationSood Ajit, Midha Vandana, Mehta Varun, Sharma Sarit, Mittal Rasham, Thara Amandeep, Sood Neena, Kaur Amarjeet. How sustained is sustained viral response in patients with hepatitis C virus infection. Indian Journal of Gastroenterology. 2010 May-Jun; 29(3): 112-115.en_US
dc.identifier.urihttps://imsear.searo.who.int/handle/123456789/141349
dc.language.isoenen_US
dc.source.urihttps://www.indianjgastro.com/IJG_pdf/may2010/May_10_4.pdfen_US
dc.subjectHepatocellular carcinomaen_US
dc.subjectPegylated interferonen_US
dc.subjectSustained viral responseen_US
dc.titleHow sustained is sustained viral response in patients with hepatitis C virus infection.en_US
dc.typeArticleen_US
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