How sustained is sustained viral response in patients with hepatitis C virus infection.
dc.contributor.author | Sood, Ajit | |
dc.contributor.author | Midha, Vandana | |
dc.contributor.author | Mehta, Varun | |
dc.contributor.author | Sharma, Sarit | |
dc.contributor.author | Mittal, Rasham | |
dc.contributor.author | Thara, Amandeep | |
dc.contributor.author | Sood, Neena | |
dc.contributor.author | Kaur, Amarjeet | |
dc.date.accessioned | 2012-09-14T03:53:45Z | |
dc.date.available | 2012-09-14T03:53:45Z | |
dc.date.issued | 2010-05 | |
dc.description.abstract | Background Sustained virological response (SVR) is achieved in a high proportion of patientswith chronic hepatitis C infection, particularly those with genotype 2 or 3 HCV infection. However, data on long-term durability of virological response in patients who achieve SVR are limited. Aim To evaluate the long-term durability of virological response in patients who have achieved SVR with interferon-based combination therapy. Methods One hundred patients with chronic HCV infection who had obtained SVR after IFN and ribavirin combination therapy were followed up for up to 8 years with annual HCV RNA testing. Results During a followed up of 6 months to 8 years, 8 of 100 patients with initial SVR developed late relapse of HCV infection. Relapse was more common in patients who had cirrhosis (5/28 [18%] vs. (3/72 [4%] with no cirrhosis; p=0.037). Conclusion SVR is durable in most patients, but some patients do have late relapse; long term follow up may be particularly important in a subset of patients with HCV infection who have liver cirrhosis. | en_US |
dc.identifier.citation | Sood Ajit, Midha Vandana, Mehta Varun, Sharma Sarit, Mittal Rasham, Thara Amandeep, Sood Neena, Kaur Amarjeet. How sustained is sustained viral response in patients with hepatitis C virus infection. Indian Journal of Gastroenterology. 2010 May-Jun; 29(3): 112-115. | en_US |
dc.identifier.uri | https://imsear.searo.who.int/handle/123456789/141349 | |
dc.language.iso | en | en_US |
dc.source.uri | https://www.indianjgastro.com/IJG_pdf/may2010/May_10_4.pdf | en_US |
dc.subject | Hepatocellular carcinoma | en_US |
dc.subject | Pegylated interferon | en_US |
dc.subject | Sustained viral response | en_US |
dc.title | How sustained is sustained viral response in patients with hepatitis C virus infection. | en_US |
dc.type | Article | en_US |