Spectrum of drug-induced liver injury in a tertiary hospital in southern India

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dc.contributor.authorKOSHY, ABRAHAMen_US
dc.contributor.authorMAHADEVAN, PUSHPAen_US
dc.contributor.authorMUKKADA, ROY Jen_US
dc.contributor.authorFRANCIS, JOSE Ven_US
dc.contributor.authorCHETTUPUZHA, ANTONY Pen_US
dc.contributor.authorAUGUSTINE, PHILIPen_US
dc.date.accessioned2023-06-27T08:32:42Z
dc.date.available2023-06-27T08:32:42Z
dc.date.issued2022-04
dc.description.abstractBACKGROUND Anti-tuberculosis drugs are thought to account for about 50% of drugs that cause liver injury in India. We show that the spectrum of drugs is much wider than previously reported. METHODS We evaluated all patients with unexplained acute liver injury presenting during 2006–2016 using a structured proforma for drug-induced liver injury (DILI). The Roussel Uclaf Causality Assessment Method was used to assess causality. RESULTS DILI was found in 143 of 2534 patients with acute liver injury. Nineteen patients had probable ayurvedic DILI. The other common causes of DILI were statins (16 patients) and anti-tuberculosis drugs (11 patients). Eight patients had DILI post-liver transplant. Fluconazole was the most common cause of post-liver transplant DILI. Chronic DILI (abnormal liver function test after 12 months of stopping the suspected drug) was found in 2 patients. CONCLUSION In otherwise unexplained acute liver injury, DILI due to ayurvedic drugs should be sought. DILI should be considered in post-liver transplant patients. Patients with DILI should be monitored for at least 12 months to exclude progression to chronic DILI.en_US
dc.identifier.affiliationsDepartment of Gastroenterology, Lakeshore Hospital, Kochi 682304, Kerala, Indiaen_US
dc.identifier.affiliationsDepartment of Pathology, Lakeshore Hospital, Kochi 682304, Kerala, Indiaen_US
dc.identifier.citationKOSHY ABRAHAM, MAHADEVAN PUSHPA, MUKKADA ROY J, FRANCIS JOSE V, CHETTUPUZHA ANTONY P, AUGUSTINE PHILIP. Spectrum of drug-induced liver injury in a tertiary hospital in southern India. The National Medical Journal of India. 2022 Apr; 35(2): 78-81en_US
dc.identifier.issn0970-258X
dc.identifier.issn2583-150X
dc.identifier.placeIndiaen_US
dc.identifier.urihttps://imsear.searo.who.int/handle/123456789/218184
dc.languageenen_US
dc.publisherAll India Institute of Medical Sciencesen_US
dc.relation.issuenumber2en_US
dc.relation.volume35en_US
dc.source.urihttps://doi.org/10.25259/NMJI_112_19en_US
dc.titleSpectrum of drug-induced liver injury in a tertiary hospital in southern Indiaen_US
dc.typeJournal Articleen_US
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