Effect of exogenous lecithin on ethanol-induced testicular injuries in Wistar rats.

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dc.contributor.authorManeesh, Men_US
dc.contributor.authorJayalekshmi, Hen_US
dc.contributor.authorDutta, Sanjibaen_US
dc.contributor.authorChakrabarti, Amiten_US
dc.contributor.authorVasudevan, D Men_US
dc.date.accessioned2005-07-31en_US
dc.date.accessioned2009-06-01T07:31:20Z
dc.date.available2005-07-31en_US
dc.date.available2009-06-01T07:31:20Z
dc.date.issued2005-07-31en_US
dc.description.abstractInfertility is well-established harmful effect in chronic alcoholism and so far, there is no effective treatment for this condition. The study was conducted to determine the effects of lecithin, a known hepatoprotective on ethanol induced testicular injuries in male albino rats of Wistar strain. Five groups (n=6) of animals were used. Group I served as control. Group II received daily 1.6 g ethanol/kg body weight/day for 4 weeks orally. Group III received 1.6 g ethanol + 500 mg lecithin/kg body weight/day for four weeks orally. Group IV received 1.6 g ethanol/kg body weight for/day 4 weeks and followed by 500 mg lecithin/kg body weight/ day for four weeks orally. Group V received 1.6 g ethanol/kg body weight/ day orally for 4 weeks, followed by 4 weeks abstinence. Twenty-four hours after the last treatment the rats were sacrificed using anesthetic ether. Testes were removed and used for the estimation of extent of lipid peroxidation and tissue levels of antioxidants and steroidogenic enzymes. Lecithin protected testes from ethanol induced oxidative stress. However, the drug did not show any considerable effect on the activities of testicular delta5, 3beta-HSD and 17beta-HSD. In conclusion, ethanol induced oxidative stress can be reversed by treatment with lecithin. However the effect of lecithin on steroidogenesis was not promising.en_US
dc.description.affiliationDepartment of Biochemistry, Sikkim Manipal Institute of Medical Sciences, Gangtok.en_US
dc.identifier.citationManeesh M, Jayalekshmi H, Dutta S, Chakrabarti A, Vasudevan DM. Effect of exogenous lecithin on ethanol-induced testicular injuries in Wistar rats. Indian Journal of Physiology and Pharmacology. 2005 Jul-Sep; 49(3): 297-304en_US
dc.identifier.urihttps://imsear.searo.who.int/handle/123456789/108218
dc.language.isoengen_US
dc.source.urihttps://www.ijpp.comen_US
dc.subject.meshAnimalsen_US
dc.subject.meshCatalase --metabolismen_US
dc.subject.meshEthanolen_US
dc.subject.meshGlutathione --metabolismen_US
dc.subject.meshGlutathione Reductase --metabolismen_US
dc.subject.meshLipid Peroxidation --drug effectsen_US
dc.subject.meshMaleen_US
dc.subject.meshOxidative Stress --drug effectsen_US
dc.subject.meshPhosphatidylcholines --administration & dosageen_US
dc.subject.meshRatsen_US
dc.subject.meshRats, Wistaren_US
dc.subject.meshSuperoxide Dismutase --metabolismen_US
dc.subject.meshTestis --drug effectsen_US
dc.titleEffect of exogenous lecithin on ethanol-induced testicular injuries in Wistar rats.en_US
dc.typeJournal Articleen_US
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