A Peripheral Smear Finding Beyond Cells: Cryoglobulins in a Case of Lymphoplasmacytic Lymphoma

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dc.contributor.authorKarthika, KVen_US
dc.contributor.authorTripathi, Pen_US
dc.contributor.authorPati, Hen_US
dc.contributor.authorSaxena, Ren_US
dc.date.accessioned2019-11-04T04:58:23Z
dc.date.available2019-11-04T04:58:23Z
dc.date.issued2019-07
dc.description.abstractA well prepared peripheral smear is an indispensable requisite for the diagnosis of hematological disorders and in some situations, non-hematological diseases. Here, we present the typical hemogram and peripheral smear findings of circulating cryoglobulins that led to the unraveling of the underlying lymphoproliferative disorder. A 51-year lady presented with symptoms of anemia since four months. Her hemogram showed anemia and leucopenia with flagging of platelet count. Peripheral smear at room temperature revealed marked artefactual changes in red blood cells including fragmentation. The morphology was better appreciated after incubating the sample at 37°C and showed normocytic normochromic RBCs, thrombocytopenia with a few lymphoplasmacytic cells and amorphous pinkish material in the background. Bone marrow examination showed near total replacement of marrow spaces by lymphoid cells positive for CD20 and CD138 and was diagnosed as lymphoplasmacytic lymphoma. Cryoglobulins can thus cause a range of laboratory artefacts which need to be recognized, warranting further search for possible underlying etiologies.en_US
dc.identifier.affiliationsDepartment of Hematology, All India Institute of Medical Sciences, New Delhi, Delhi, India; karthika.kv@gmail.comen_US
dc.identifier.affiliationscontactdoctorpreeti@gmail.comen_US
dc.identifier.affiliationsharappati@yahoo.co.inen_US
dc.identifier.affiliationsrenusaxena@outlook.comen_US
dc.identifier.citationKarthika KV, Tripathi P, Pati H, Saxena R. A Peripheral Smear Finding Beyond Cells: Cryoglobulins in a Case of Lymphoplasmacytic Lymphoma. International Journal of Medical and Dental Sciences. 2019 Jul; 8(2): 1744-1748en_US
dc.identifier.issn2454-8952
dc.identifier.issn2320-1118
dc.identifier.placeIndiaen_US
dc.identifier.urihttps://imsear.searo.who.int/handle/123456789/183630
dc.languageenen_US
dc.publisherDr. J.S. Sodhi Memorial Educational Societyen_US
dc.relation.issuenumber2en_US
dc.relation.volume8en_US
dc.source.urihttps://doi.org/10.18311/ijmds/2019/23294en_US
dc.subjectArtifactsen_US
dc.subjectCryoglobulinemiaen_US
dc.subjectPeripheral-Smearen_US
dc.subjectPseudothrombocytosisen_US
dc.subjectHematologyen_US
dc.titleA Peripheral Smear Finding Beyond Cells: Cryoglobulins in a Case of Lymphoplasmacytic Lymphomaen_US
dc.typeJournal Articleen_US
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