Neuroprotective effect of Annona squamosa & (-) Anonaine in decreased GABA receptor of epileptic rats.

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dc.contributor.authorPorwal, Mayur
dc.contributor.authorKumar, Arvind
dc.date.accessioned2015-07-07T09:22:30Z
dc.date.available2015-07-07T09:22:30Z
dc.date.issued2015-05
dc.description.abstractAnnona squamosa and its active alkaloid content (-) Anonaine are known for antiepileptic activity on the basis of literature review. The objective of this study was to establish neuroprotection by Annona squamosa and its active alkaloid content (-) Anonaine as an antiepileptic agent by acting on GABA receptor. For neuroprotective assessment, variations of GABA, GABAA, GABAB receptors in the cortex region of the brain in epileptic rats and potential applications of Annona squamosa and its isolated chemical constituent (Anonaine) were investigated by using confocal microscopy. Nootropic activity in epileptic rats was also studied by radial and Y-maze model. GABA receptor binding analysis in the cortex region of epileptic rats showed significant decrease in Bmax (p<0.001) compared to control. Microscopic (confocal) study reveals confirmed decreased GABA receptors in epileptic rats. The extract of Annona squamosa leaves and its isolated constituent- anonaine showed memory boosting and memory regaining effects in radial arm and y-maze model. From the above data and findings, we may conclude that extract of Annona squamosa leaves and its alkaloidal constituent- anonaine improves significant changes in epileptic rat’s behavior and their decreased GABA receptors. Both extract and its isolated component in future may be evaluated in further studies.en_US
dc.identifier.citationPorwal Mayur, Kumar Arvind. Neuroprotective effect of Annona squamosa & (-) Anonaine in decreased GABA receptor of epileptic rats. Journal of Applied Pharmaceutical Science. 2015 May; 5(suppl_1): s18-s23.en_US
dc.identifier.issn2231-3354
dc.identifier.urihttps://imsear.searo.who.int/handle/123456789/159233
dc.language.isoenen_US
dc.source.urihttps://www.japsonline.com/counter.php?aid=1491en_US
dc.subjectNeuroprotectiveen_US
dc.subjectAnnona squamosaen_US
dc.subjectanonaineen_US
dc.subjectGABAen_US
dc.subjectepilepsyen_US
dc.subjectConfocal microscopyen_US
dc.titleNeuroprotective effect of Annona squamosa & (-) Anonaine in decreased GABA receptor of epileptic rats.en_US
dc.typeArticleen_US
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