Nasopharyngeal carcinoma in Indonesia has a low prevalence of the 30-base pair deletion of Epstein-Barr virus latent membrane protein 1.

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dc.contributor.authorNurhantari, Yudhaen_US
dc.contributor.authorEmoto, Noriakien_US
dc.contributor.authorRahayu, Pudjien_US
dc.contributor.authorMatsuo, Masafumien_US
dc.date.accessioned2009-05-27T15:40:12Z
dc.date.available2009-05-27T15:40:12Z
dc.date.issued2003-03-16en_US
dc.descriptionThe Southeast Asian Journal of Tropical Medicine and Public Health.en_US
dc.description.abstractEpstein-Barr virus (EBV) is associated with nasopharyngeal carcinoma (NPC), one of the highest incidence of tumors in Indonesia. EBV infection is ubiquitous around the world, but NPC occurs with a remarkable geographic distribution. This phenomenon suggests that there are subtypes of EBV, some of which may have greater tumorigenic potential. The latent membrane protein 1 (LMP 1) gene encoded by EBV is tumorigenic due to its ability to transform rodent fibroblast. It was originally shown that the LMP 1 gene from NPC of Chinese patients harbors a deletion of 30-bp in the carboxyl terminal of the gene. However, the deletion is also present in healthy control and in other EBV-positive tumors. We examined the polymorphism of LMP 1 in 56 tumor biopsies of Indonesian patients with NPC and identified low prevalence of the 30-bp deletion of LMP 1. Sequence analysis showed unique mutations of LMP 1 which suggests that strain-specific variations of EBV are found in Indonesia. The low frequency of 30-bp deletion in the country with high prevalence of NPC indicates that the deletion may represent a geographic polymorphism rather than a predisposing factor in the development of NPC.en_US
dc.description.affiliationInternational Center for Medical Research, Kobe University Graduate School of Medicine, Kobe, Japan.en_US
dc.identifier.citationNurhantari Y, Emoto N, Rahayu P, Matsuo M. Nasopharyngeal carcinoma in Indonesia has a low prevalence of the 30-base pair deletion of Epstein-Barr virus latent membrane protein 1. The Southeast Asian Journal of Tropical Medicine and Public Health. 2003 Mar; 34(1): 98-105en_US
dc.identifier.urihttps://imsear.searo.who.int/handle/123456789/33365
dc.language.isoengen_US
dc.source.urihttps://www.tm.mahidol.ac.th/seameo/2003_34_1/14-3004.pdfen_US
dc.subject.meshCarcinoma --epidemiologyen_US
dc.subject.meshGene Deletionen_US
dc.subject.meshHumansen_US
dc.subject.meshIndonesia --epidemiologyen_US
dc.subject.meshMolecular Sequence Dataen_US
dc.subject.meshNasopharyngeal Neoplasms --epidemiologyen_US
dc.subject.meshPolymerase Chain Reactionen_US
dc.subject.meshPolymorphism, Geneticen_US
dc.subject.meshPrevalenceen_US
dc.subject.meshViral Matrix Proteins --geneticsen_US
dc.titleNasopharyngeal carcinoma in Indonesia has a low prevalence of the 30-base pair deletion of Epstein-Barr virus latent membrane protein 1.en_US
dc.typeJournal Articleen_US
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