A comparative study of postoperative hypocalcaemia following total thyroidectomy in patients with Hashimoto’s thyroiditis and multinodular goitre in a rural tertiary care hospital

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dc.date.accessioned2020-11-18T10:05:01Z
dc.date.available2020-11-18T10:05:01Z
dc.date.issued2020-08
dc.description.abstractBackground: Recurrent laryngeal nerve injury, hypothyroidism and hypocalcaemia have long been recognized as the three main sequalae of thyroidectomy. Persistent hypocalcaemia may cause intracranial lesions and cardiac arrhythmias. As the definitive diagnosis of Hashimoto’s thyroiditis was not always possible with clinical and cytological parameters when antibody testing was not done, surgery was planned with the diagnosis of multinodular goitre. This study was conducted to find out the incidence of post-operative hypocalcaemia following total thyroidectomy by skilled surgeons in patients with multinodular goitre and Hashimoto’s thyroiditis.Methods: This was a cross-sectional study to compare the incidence of hypocalcaemia in patients with biopsy-proven Hashimoto’s thyroiditis and multinodular goitre. After obtaining approval from the institutional review board and ethics committee, data was collected serially, from the surgical records of 123 patients who underwent total thyroidectomy in this tertiary care centre, during the past two years.Results: The incidence of post-operative hypocalcaemia (71.1%) in patients undergoing total thyroidectomy with Hashimoto’s thyroiditis was significantly higher than in patients with multinodular goitre (56.4%). Of the 45 patients who had a biopsy report of Hashimoto’s thyroiditis, 8 (17.8 %) developed permanent hypocalcaemia while only 8 (10.3%) of the 78 patients with histopathological diagnosis of multinodular goitre developed persistent hypocalcaemia needing supplementation following total thyroidectomy in this rural tertiary care hospital.Conclusions: The significant risk of post-operative hypocalcaemia should be kept in mind before opting for total thyroidectomy for benign lesions of the thyroid and pre-operative antibody studies must be done to diagnose Hashimoto’s thyroiditis.en_US
dc.identifier.affiliationsMedical Student, MOSC Medical College, Kolenchery, Kerala, Indiaen_US
dc.identifier.affiliationsDepartment of Surgery, MOSC Medical College, Kolenchery, Kerala, Indiaen_US
dc.identifier.affiliationsDepartment of Pharmacology, MOSC Medical College, Kolenchery, Kerala, Indiaen_US
dc.identifier.affiliationsBiostatistician, St. Johns Medical College, Bengaluru, Karnataka, Indiaen_US
dc.identifier.citationP. Amrutha, Joseph Arun P., Mathew Anna, Raj John Michael. A comparative study of postoperative hypocalcaemia following total thyroidectomy in patients with Hashimoto’s thyroiditis and multinodular goitre in a rural tertiary care hospital. International Surgery Journal. 2020 Aug; 7(8): 2668-2673en_US
dc.identifier.issn2349-3305
dc.identifier.issn2349-2902
dc.identifier.placeIndiaen_US
dc.identifier.urihttps://imsear.searo.who.int/handle/123456789/213104
dc.languageenen_US
dc.publisherMedip Academyen_US
dc.relation.issuenumber8en_US
dc.relation.volume7en_US
dc.source.urihttps://dx.doi.org/10.18203/2349-2902.isj20203253en_US
dc.subjectHashimoto’s thyroiditisen_US
dc.subjectHypocalcaemiaen_US
dc.subjectMultinodular goitreen_US
dc.subjectTotal thyroidectomyen_US
dc.titleA comparative study of postoperative hypocalcaemia following total thyroidectomy in patients with Hashimoto’s thyroiditis and multinodular goitre in a rural tertiary care hospitalen_US
dc.typeJournal Articleen_US
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