Diversity & overlap in the mechanisms of processing protein antigens for presentation to T cells.

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dc.contributor.authorRajagopal, Deepaen_US
dc.contributor.authorBal, Vineetaen_US
dc.contributor.authorGeorge, Annaen_US
dc.contributor.authorRath, Satyajiten_US
dc.date.accessioned2004-08-07en_US
dc.date.accessioned2009-05-27T06:44:50Z
dc.date.available2004-08-07en_US
dc.date.available2009-05-27T06:44:50Z
dc.date.issued2004-08-07en_US
dc.description67 references.en_US
dc.description.abstractThe immune system needs to recognise target protein antigens from pathogens residing in both extracellular and intracellular locations. Intricate proteolytic processing events that follow antigen/ pathogen encounter provide the immune system with a complex display of a heterogeneous peptide mix, instrumental in the initiation of T cell immune responses, and allow the separation of extracellular and intracellular pathogen identification. However, recent evidence shows that this conventional dimorphism in the proteolytic processing of endogenous versus internalised antigen is less restrictive than originally recognized. The events that constitute the conventional major histocompatibility complex (MHC)-restricted processing pathways are accompanied by interesting deviations that provide novel adjuncts for the processing machinery to gain access to antigen in varied intracellular locations. This review discusses these aspects of classical and non-classical processing pathways for MHC-restricted protein presentation, which play significant roles in both optimising and diversifying the peptide repertoire available for immune recognition.en_US
dc.description.affiliationImmunobiology Laboratory, National Institute of Immunology, New Delhi, India. deepa@nii.res.inen_US
dc.identifier.citationRajagopal D, Bal V, George A, Rath S. Diversity & overlap in the mechanisms of processing protein antigens for presentation to T cells. Indian Journal of Medical Research. 2004 Aug; 120(2): 75-85en_US
dc.identifier.urihttps://imsear.searo.who.int/handle/123456789/17723
dc.language.isoengen_US
dc.source.urihttps://icmr.nic.in/ijmr/ijmr.htmen_US
dc.subject.meshAntigen Presentationen_US
dc.subject.meshAntigens --immunologyen_US
dc.subject.meshEndopeptidases --metabolismen_US
dc.subject.meshHistocompatibility Antigens Class Ien_US
dc.subject.meshHistocompatibility Antigens Class IIen_US
dc.subject.meshHumansen_US
dc.subject.meshMajor Histocompatibility Complex --immunologyen_US
dc.subject.meshMolecular Chaperones --metabolismen_US
dc.subject.meshT-Lymphocytes --immunologyen_US
dc.titleDiversity & overlap in the mechanisms of processing protein antigens for presentation to T cells.en_US
dc.typeJournal Articleen_US
dc.typeReviewen_US
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