Correlation of in vitro Fc receptor assay with in vivo mouse foot pad method.

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dc.contributor.authorJagannathan, Ren_US
dc.contributor.authorPatil, Den_US
dc.contributor.authorMahadevan, P Ren_US
dc.date.accessioned1988-10-01en_US
dc.date.accessioned2009-05-28T10:00:37Z
dc.date.available1988-10-01en_US
dc.date.available2009-05-28T10:00:37Z
dc.date.issued1988-10-01en_US
dc.description.abstractResistant strains of M. leprae have been reported to the various antileprosy drugs. There is currently no accepted test to identify the susceptibility pattern of M. leprae to the drugs in a short period. The only accepted test is the mouse foot method which takes a long period to yield results. The Fc receptor assay using the ability of viable M. leprae to alter the membrane of the macrophage is well established. It takes only ten days and is inexpensive. In 6 cases of leprosy patients the susceptibility pattern was worked out both with the in vitro Fc receptor assay and the vivo in mouse foot method The results correlated very well leading to the fact that the assay system is reliable. Hence it can be used not only to study the status of a patient, but also to shortlist the number of compounds to be tested on the mouse foot pad as anti-leprosy drug candidates.en_US
dc.description.affiliationFoundation for Medical Research, Bombay.en_US
dc.identifier.citationJagannathan R, Patil D, Mahadevan PR. Correlation of in vitro Fc receptor assay with in vivo mouse foot pad method. Indian Journal of Leprosy. 1988 Oct; 60(4): 517-25en_US
dc.identifier.urihttps://imsear.searo.who.int/handle/123456789/54719
dc.language.isoengen_US
dc.subject.meshAnimalsen_US
dc.subject.meshDrug Evaluation, Preclinical --methodsen_US
dc.subject.meshFluoresceins --diagnostic useen_US
dc.subject.meshLeprosy --drug therapyen_US
dc.subject.meshMacrophages --immunologyen_US
dc.subject.meshMiceen_US
dc.subject.meshMycobacterium leprae --drug effectsen_US
dc.subject.meshReceptors, Fc --analysisen_US
dc.titleCorrelation of in vitro Fc receptor assay with in vivo mouse foot pad method.en_US
dc.typeComparative Studyen_US
dc.typeJournal Articleen_US
dc.typeResearch Support, Non-U.S. Gov'ten_US
dc.typeResearch Support, U.S. Gov't, P.H.S.en_US
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