Diagnostic Efficacy of Radiology in the Diagnosis of Giant Cell Tumour of Bone.
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Date
2014-01
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Abstract
Background: Giant cell tumour (GCT) is an aggressive and potentially malignant lesion. Microscopic feature
reveals osteoclast like giant cells in a mononuclear stromal cells background. The mononuclear stromal cell is
interpreted as neoplastic. Objective: As radiological diagnosis is non invasive and cost effective in comparison to
histopathological diagnosis, considering the patients’ compliance, the aim of the study was to observe the
diagnostic efficacy of radiology in diagnosis of GCT. Materials and method: This cross sectional study was
carried out in the department of Pathology, Delta Hopital Ltd., Dhaka, Bangladesh from July 2011 to December
2012. A total of 30 study subjects were enrolled in the study irrespective of age and sex. Biopsy material and
relevant data of clinically suspected cases of GCT along with radiology report were sent from National Institute
of Traumatology and Orthopaedic Rehabilitation (NITOR), Dhaka, Bangladesh. Histopathological diagnosis was
made by expert pathologists. Results: Mean (±SD) age of the study subjects was 29.20 (±7.34) years with highest
number of patients were observed in 3rd decade and female was predominant (60%) with a male female ratio of
1:1.5. Common site of GCT was around knee (50%). Among 30 clinically diagnosed GCT, 25 (83.3%) cases were
radiologically diagnosed as GCT, 2 (6.7%) diagnosed as fibrous dysplasia, 1 (3.3%) as chondroblastoma, 1
(3.3%) as simple bone cyst and 1 (3.3%) as aneurysmal bone cyst. However among 30 clinically diagnosed GCT,
28 (93.3%) patients were histopathologically diagnosed as Giant cell lesion and rest 2 (6.7%) patients diagnosed
as fibrous dysplasia. The sensitivity, specificity, positive predictive value, negative predictive value and accuracy
of radiological diagnosis of GCT were found to be 92.6%, 100.0%, 100.0%, 40.0% and 90.0%, respectively.
Conclusion: Radiology can be effectively used as a screening tool in diagnosing GCT.
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Keywords
Giant cell tumour, radiology
Citation
Akhter Afia, Saleheen Mohammad Serajus, Majid Nadira, Salahuddin Syed, Afroz Kwazi Dil, Rahman Md Rezwanur, Ali Syed Makarram. Diagnostic Efficacy of Radiology in the Diagnosis of Giant Cell Tumour of Bone. Delta Medical College Journal. 2014 Jan; 2(1): 13-16.