Changes in peripheral insulin concentrations in non insulin dependent diabetes during treatment. Assessment by mathematical applications.

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dc.contributor.authorRamachandran, Aen_US
dc.contributor.authorSnehalatha, Cen_US
dc.contributor.authorMohan, Ven_US
dc.contributor.authorTimothy, Hen_US
dc.contributor.authorViswanathan, Men_US
dc.date.accessioned1990-09-01en_US
dc.date.accessioned2009-05-30T19:03:07Z
dc.date.available1990-09-01en_US
dc.date.available2009-05-30T19:03:07Z
dc.date.issued1990-09-01en_US
dc.description.abstractSerum immunoreactive insulin responses to meal stimulus were studied in 20 newly detected non insulin dependent diabetes mellitus patients, following one week of treatment with high carbohydrate, high fibre diet and glibenclamide. Ten patients showed "rapid glycaemic response" i.e. the glycaemic response was good within a week. The rest of them were called "slow responders". The insulin responses were heterogenous. Mathematical calculations using the glucose and insulin responses showed improved beta cell function and peripheral action of insulin in rapid responders. On the other hand, the slow responders showed only slightly improved beta cell function with no change in peripheral action of insulin. The second phase of the study constituted follow-up studies upto 6 months. The corrected insulin response (CIR) increased initially in several patients. The peripheral insulin action improved in all patients with longer duration of treatment and lower insulin concentrations were required to maintain normoglycaemia at this stage. The results of the study indicate that a) multiple factors influence glucoregulation, b) even short term effects of the drug appear to be mediated by extra pancreatic mechanisms, and c) the extrapancreatic action improves significantly on long term use of the drug.en_US
dc.description.affiliationDepartment of Biochemistry, Diabetes Research Centre, Madras.en_US
dc.identifier.citationRamachandran A, Snehalatha C, Mohan V, Timothy H, Viswanathan M. Changes in peripheral insulin concentrations in non insulin dependent diabetes during treatment. Assessment by mathematical applications. Journal of the Association of Physicians of India. 1990 Sep; 38(9): 625-8en_US
dc.identifier.urihttps://imsear.searo.who.int/handle/123456789/86415
dc.language.isoengen_US
dc.source.urihttps://www.japi.orgen_US
dc.subject.meshAdulten_US
dc.subject.meshBlood Glucose --analysisen_US
dc.subject.meshDiabetes Mellitus, Type 2 --blooden_US
dc.subject.meshEating --physiologyen_US
dc.subject.meshEvaluation Studies as Topicen_US
dc.subject.meshFemaleen_US
dc.subject.meshFollow-Up Studiesen_US
dc.subject.meshGlyburide --therapeutic useen_US
dc.subject.meshHumansen_US
dc.subject.meshInsulin --blooden_US
dc.subject.meshMaleen_US
dc.subject.meshMathematicsen_US
dc.subject.meshMiddle Ageden_US
dc.titleChanges in peripheral insulin concentrations in non insulin dependent diabetes during treatment. Assessment by mathematical applications.en_US
dc.typeJournal Articleen_US
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