Clinicopathological spectrum of 19 adenosarcomas of female genital tract, including uncommon clinical associations and immunohistochemical profile, reviewed at a single institution.

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dc.contributor.authorRekhi, Bharat
dc.contributor.authorDeodhar, Kedar K
dc.contributor.authorMaheshwari, Amita
dc.contributor.authorMenon, Santosh
dc.contributor.authorKerkar, Rajendra
dc.contributor.authorBajpai, Jyoti
dc.contributor.authorGhosh, Jaya
dc.contributor.authorGupta, Sudeep
dc.contributor.authorEngineer, Reena
dc.contributor.authorShrivastava, Shyam K
dc.date.accessioned2012-10-18T05:11:37Z
dc.date.available2012-10-18T05:11:37Z
dc.date.issued2012-07
dc.description.abstractBackground: Adenosarcomas of the female genital tract have been rarely documented as case series from our continent. Materials and Methods: Over a seven-year period, 19 adenosarcomas were critically reviewed. Results: Nineteen tumors occurred in the age range of 21-65 years (mean: 43), in the endometrium (8), endometrium and cervix (4), cervix (4), and ovary (3). Four cases displayed coexisting leiomyomas; two, adenomyosis; two on background endometriosis; and one in post-treated cervix carcinoma. Histopathologically, the tumors were low grade (10; 52.6%) and high grade (9; 47.3%), the latter with sarcomatous overgrowth (SO) (7/9 cases). Dedifferentiation (8, 42.1%) and conspicuous decidualization (2) were noted. Immunohistochemically, the tumors focally expressed CD10 (4/6), smooth muscle actin (SMA) (3/8), desmin (8/11); diffuse vimentin (7/7), and estrogen receptor/progesterone receptor (ER/PR) (2/4). Ki-67 (6 cases) varied 5-20%. Seventeen patients underwent surgery and four received adjuvant treatment (3/4 high-grade tumors). Five tumors recurred (4 high-grade tumors with SO) and one metastasized. Among 11 patients, five were alive with disease (AWD) (mean: 29.4 months) and six, free of disease (FOD) (mean: 15 months), the latter mostly with low-grade type tumors (83.3% cases). Conclusions: Diverse clinicopathological spectrum was noted within adenosarcomas. Low-grade tumors were less aggressive than high-grade ones, with SO. Immunohistochemically, lower CD10 and ER/PR positivity was noted in high-grade tumors. Surgery formed the mainstay of treatment. Adjuvant treatment was offered in high-grade subtypes, including in tumors with SO.en_US
dc.identifier.citationRekhi Bharat, Deodhar Kedar K, Maheshwari Amita, Menon Santosh, Kerkar Rajendra, Bajpai Jyoti, Ghosh Jaya, Gupta Sudeep, Engineer Reena, Shrivastava Shyam K. Clinicopathological spectrum of 19 adenosarcomas of female genital tract, including uncommon clinical associations and immunohistochemical profile, reviewed at a single institution. Indian Journal of Pathology & Microbiology. 2012 Jul-Sept 55(3): 326-332.en_US
dc.identifier.urihttps://imsear.searo.who.int/handle/123456789/142261
dc.language.isoenen_US
dc.source.urihttps://www.ijpmonline.org/article.asp?issn=0377-4929;year=2012;volume=55;issue=3;spage=326;epage=332;aulast=Rekhien_US
dc.subjectAdenosarcomaen_US
dc.subjectmesenchymal tumors of female genital tracten_US
dc.subjectMullerian adenosarcomaen_US
dc.subjectuterine sarcomasen_US
dc.subject.meshAdenosarcoma --pathology
dc.subject.meshAdult
dc.subject.meshAged
dc.subject.meshAntigens, Neoplasm --analysis
dc.subject.meshFemale
dc.subject.meshGenital Neoplasms, Female --pathology
dc.subject.meshHistocytochemistry
dc.subject.meshHumans
dc.subject.meshImmunohistochemistry
dc.subject.meshMicroscopy
dc.subject.meshMiddle Aged
dc.subject.meshYoung Adult
dc.titleClinicopathological spectrum of 19 adenosarcomas of female genital tract, including uncommon clinical associations and immunohistochemical profile, reviewed at a single institution.en_US
dc.typeArticleen_US
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