Multicentric study of efficacy and safety of growth hormone use in growth hormone deficient children in India.

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dc.contributor.authorKhadilkar, V Ven_US
dc.contributor.authorKhadilkar, A Ven_US
dc.contributor.authorNandy, Men_US
dc.contributor.authorMaskati, G Ben_US
dc.date.accessioned2007-01-01en_US
dc.date.accessioned2009-05-30T10:22:30Z
dc.date.available2007-01-01en_US
dc.date.available2009-05-30T10:22:30Z
dc.date.issued2007-01-01en_US
dc.description.abstractGrowth Hormone being very expensive in India data on use of recombinant human growth hormone (rhGH) is scarce. The authors studied the effect and safety of one year of therapy with rhGH on growth velocity and predicted final height in Indian patients with growth hormone deficiency (GHD). A multicentric, prospective, open trial with rhGH was performed on 15 patients. Patients received rhGH in a dose of 0.7 IU (0.23 mg)/Kg/week. The mean pretreatment height was 111.2 cms {SD 12.4}, height velocity was 3.1 cms per year {1.2} and predicted height was 146.5 cms {10.4} at a mean age of 12.0 (2.8). At the end of therapy mean height was 123.4 {11.9}, height velocity was 12.1 cms per year {2.8} and the predicted height was 153.0 cm {9.4}. The increase in predicted height was thus 6.5 cm (4.2). The increment in height velocity with growth hormone therapy was statistically significant (p value= 0.001). The present study shows that children with growth hormone deficiency in India also benefit from therapy with rhGH even when treatment is started late as compared to the published Western data and there is a potential for increased final height.en_US
dc.description.affiliationMedical Services and Product Development, LG Life Sciences India Pvt. Ltd., Hirabai Cowasji Jehangir Medical Research Institute, Jehangir Hospital, Pune, India. akhadilkar@vsnl.neten_US
dc.identifier.citationKhadilkar VV, Khadilkar AV, Nandy M, Maskati GB. Multicentric study of efficacy and safety of growth hormone use in growth hormone deficient children in India. Indian Journal of Pediatrics. 2007 Jan; 74(1): 51-4en_US
dc.identifier.urihttps://imsear.searo.who.int/handle/123456789/78579
dc.language.isoengen_US
dc.source.urihttps://medind.nic.in/icb/icbai.shtmlen_US
dc.subject.meshAdolescenten_US
dc.subject.meshAge Factorsen_US
dc.subject.meshBody Height --drug effectsen_US
dc.subject.meshChilden_US
dc.subject.meshDose-Response Relationship, Drugen_US
dc.subject.meshDrug Administration Scheduleen_US
dc.subject.meshDrug Toxicityen_US
dc.subject.meshFemaleen_US
dc.subject.meshFollow-Up Studiesen_US
dc.subject.meshGrowth Disorders --drug therapyen_US
dc.subject.meshHuman Growth Hormone --deficiencyen_US
dc.subject.meshHumansen_US
dc.subject.meshIndiaen_US
dc.subject.meshInjections, Subcutaneousen_US
dc.subject.meshMaleen_US
dc.subject.meshProspective Studiesen_US
dc.subject.meshRisk Factorsen_US
dc.subject.meshSeverity of Illness Indexen_US
dc.subject.meshSex Factorsen_US
dc.subject.meshTreatment Outcomeen_US
dc.titleMulticentric study of efficacy and safety of growth hormone use in growth hormone deficient children in India.en_US
dc.typeClinical Trialen_US
dc.typeJournal Articleen_US
dc.typeMulticenter Studyen_US
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