Usefulness of anti -CCP antibodies in rheumatic diseases in Indian patients.

Simple item page
dc.contributor.authorGupta, Rajivaen_US
dc.contributor.authorThabah, Molly Men_US
dc.contributor.authorAneja, Rituen_US
dc.contributor.authorKumar, Ashoken_US
dc.contributor.authorVarghese, Titusen_US
dc.contributor.authorChandrasenan, P Jen_US
dc.date.accessioned2009-03-11en_US
dc.date.accessioned2009-05-29T05:18:45Z
dc.date.available2009-03-11en_US
dc.date.available2009-05-29T05:18:45Z
dc.date.issued2009-03-11en_US
dc.description.abstractBACKGROUND: The usefulness of anti-cyclic citrullinated peptide antibodies (anti-CCP antibodies) to identify rheumatic arthritis (RA) from other rheumatic diseases presenting with joint pain is not well studied. AIMS: We aimed to determine the sensitivity and specificity of anti-CCP antibodies in Indian RA patients with respect to non-RA rheumatic diseases and to study the relationship of anti-CCP antibodies and IgG, IgM and IgA rheumatoid factor in RA. SETTINGS AND DESIGN: Case-control cross-sectional study carried out in the rheumatology division of All India Institute of Medical Sciences. MATERIALS AND METHODS: Sixty-three patients with rheumatoid arthritis (RA) and 51 patients with non-RA rheumatic diseases having joint pain were included in the study. Sera were tested for anti-CCP antibodies (IgG) and IgA, IgM, IgG rheumatoid factor, using a commercially available enzyme-linked immunosorbent assay. STATISTICAL ANALYSIS: Statistical analysis was performed using SPSS statistical software version 11.5. RESULTS: Fifty-four of 63 RA patients (85.71%) were positive for anti-CCP antibodies. In the non-RA group, anti-CCP antibody was positive in only 5 of 51 patients (9.8%). Our study found a sensitivity of 85% and a specificity of 90.19% with regard to the use of anti-CCP antibodies assay in patients with joint pain to correctly identify RA. Anti-CCP antibodies positive patients did not have more erosive disease. IgM-RF-positive patients had more erosion when compared to the IgM-RF-negative group. Thirty-two of 57 (56.1%) IgM-RF-positive patients had erosions, while no patient (0/6 patients) had erosions in the IgM-RF-negative group (P=0.01) CONCLUSION: Anti-CCP antibodies have high sensitivity and specificity for diagnosis of RA, in Indian patients. Anti-CCP antibodies positive patients did not have more erosive disease in our study.en_US
dc.description.affiliationDepartment of Medicine, Clinical Immunology and Rheumatology Services, All India Institute of Medical Sciences, New Delhi-110 029, India. guptarajiva@hotmail.comen_US
dc.identifier.citationGupta R, Thabah MM, Aneja R, Kumar A, Varghese T, Chandrasenan PJ. Usefulness of anti -CCP antibodies in rheumatic diseases in Indian patients. Indian Journal of Medical Sciences. 2009 Mar; 63(3): 92-100en_US
dc.identifier.urihttps://imsear.searo.who.int/handle/123456789/67504
dc.language.isoengen_US
dc.source.urihttps://www.indianjmedsci.orgen_US
dc.subject.meshAdult
dc.subject.meshArthritis, Rheumatoid --diagnosis
dc.subject.meshAutoantibodies --blood
dc.subject.meshHumans
dc.subject.meshPeptides, Cyclic --immunology
dc.subject.meshIndia
dc.subject.meshPatients
dc.subject.meshRheumatic Diseases --diagnosis
dc.subject.meshRheumatoid Factor --blood
dc.subject.meshSensitivity and Specificity
dc.titleUsefulness of anti -CCP antibodies in rheumatic diseases in Indian patients.en_US
dc.typeJournal Articleen_US
Files
License bundle
Now showing 1 - 1 of 1
No Thumbnail Available
Name:
license.txt
Size:
1.79 KB
Format:
Plain Text
Description:
Download
Collections
Indian Journal of Medical Sciences