Interaction of amino acids with glycyl-glycine transport in the mammalian intestine.
| dc.contributor.author | Ganapathy, V | |
| dc.contributor.author | Hellier, M D | |
| dc.contributor.author | Radhakrishnan, A N | |
| dc.date.accessioned | 2015-07-17T05:48:48Z | |
| dc.date.available | 2015-07-17T05:48:48Z | |
| dc.date.issued | 1979-03 | |
| dc.description.abstract | In order to investigate a possible interaction between free amino acids and dipeptides during their mucosal uptake in man and monkey, perfusion studies in vivo and uptake studies in vitro using labelled and non-labelled dipeptides and amino acids have been carried out. In contrast to the observations of other workers, inhibition of glycyl-glycine uptake was observed with free leucine and methioninc but not with glycine, proline, hydroxyproline or alanine. Leucine and methionine caused inhibition of cytosol glycyl-glycine hydrolase activity, while glycine had no effect. The dipeptide uptake and dipeptide hydrolysis by cytosol enzyme was competitively inhibited by leucine. Although brush border glycyl-glycine hydrolase was also inhibited by leucine, the inhibition was noncompetitive. These data indicate that a few free amino acids can interact with dipeptides during uptake. This interaction might occur either at the transport step or at the stage of intracellular dipeptide hydrolysis. | en_US |
| dc.identifier.citation | Ganapathy V, Hellier M D, Radhakrishnan A N. Interaction of amino acids with glycyl-glycine transport in the mammalian intestine. Journal of Biosciences. 1979 Mar; 1(1): 1-12. | en_US |
| dc.identifier.uri | https://imsear.searo.who.int/handle/123456789/159917 | |
| dc.language.iso | en | en_US |
| dc.source.uri | https://www.ias.ac.in/jarch/jbiosci/1/1-12.pdf | en_US |
| dc.subject | Intestine | en_US |
| dc.subject | peptide transport | en_US |
| dc.subject | peptidases | en_US |
| dc.subject | amino acid interaction | en_US |
| dc.title | Interaction of amino acids with glycyl-glycine transport in the mammalian intestine. | en_US |
| dc.type | Article | en_US |