Evaluation of asprosin levels in growth hormone-deficient children.
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Date
2024-12
Journal Title
Journal ISSN
Volume Title
Publisher
Dr. M. V. Ghorpade
Abstract
Background: Growth Hormone Deficiency (GHD) in children is a rare endocrine condition characterized by a low GH secretion that minimizes the secretion of growth factors such as Insulin-Like Growth Factor-I (IGF-I). Asprosin (ASP), a novel adipokine predominantly secreted by white adipose tissue, plays a crucial role in the liver's production of glucose. Elevated levels of ASP are observed in metabolic diseases. Aim and Objectives: This study aimed to assess the levels of ASP in pediatric patients with GHD. Material and Methods: This research included 40 subjects (children) with GHD and 50 healthy control subjects, with measurements conducted using ELISA kits for ASP. Results: We found the levels of ASP to be significantly higher in the patient group (mean 5.7, range 2.28-17.79 ng/ml) compared to the control group (mean 4.1, range 3.12-5.21 ng/ml) (p < 0.001). Conclusion: This finding suggests a potential link between GHD and altered ASP secretion. Elevated levels of ASP in GHD patients may contribute to metabolic dysregulation, insulin resistance, and other associated complications.
Description
Keywords
Asprosin, Growth hormone, FBN1, IGF-1, Insulin resistance
Citation
Safaa EA, Marwa AH, Omar YS, Karam G, Isam NS.. Evaluation of asprosin levels in growth hormone-deficient children.. Journal of Krishna Institute of Medical Sciences University. 2024 Dec; 13(4): 65-73