Protective Effect of Adiantum Capillus Against Chemically Induced Oxidative Stress by Cisplatin.

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dc.contributor.authorGaikwad, Kanchan
dc.contributor.authorDhande, Swati
dc.contributor.authorJoshi, Y M
dc.contributor.authorKadam, Vilasrao
dc.date.accessioned2014-05-31T05:26:48Z
dc.date.available2014-05-31T05:26:48Z
dc.date.issued2013-02
dc.description.abstractDamage to cells caused by free radicals has been implicated in the disease progression of at least 50 diseases that is cancer, cardiovascular disease, renal dysfunction and other. So many factors contribute to oxidative stress. Hence, the present study was designed to investigate the potential nephroprotective activity of 250mg/kg and 500mg/kg. Ethanolic extract of Adiantum capillus-veneris dried fronds against Cisplatin induced oxidative stress caused in male Wistar rats. Acute nephrotoxicity was induced by i.p. injection of Cisplatin (7 mg/kg of body weight (b.w.)). Administration of ethanol extract at dose level of 500 and 250 mg/kg (b.w.) to Cisplatin-intoxicated rats (toxic control) for 14 days attenuated the biochemical and histological signs of nephrotoxicity of Cisplatin in dose-dependent fashion. Ethanol extract at 500 mg/kg decreased the serum level of creatinine and urea as compared to the toxic control group. The ethanol extract of Adiantum capillus-veneris at 500 mg/kg (b.w.) exhibited significant and comparable nephroprotective potential. The statistically (one-way-ANOVA followed by Dunnet’s test) processed results suggested the positive action of Adiantum capillus-veneris Cisplatin-induced nephropathy.en_US
dc.identifier.citationGaikwad Kanchan, Dhande Swati, Joshi Y M, Kadam Vilasrao. Protective Effect of Adiantum Capillus Against Chemically Induced Oxidative Stress by Cisplatin. Journal of Applied Pharmaceutical Science. 2013 Feb; 3(2): 65-68.en_US
dc.identifier.urihttps://imsear.searo.who.int/handle/123456789/151542
dc.language.isoenen_US
dc.source.urihttps://www.japsonline.com/counter.php?aid=788en_US
dc.subjectCisplatin nephrotoxicityen_US
dc.subjectAdiantum capillus-venerisen_US
dc.subjectethanolic extracten_US
dc.titleProtective Effect of Adiantum Capillus Against Chemically Induced Oxidative Stress by Cisplatin.en_US
dc.typeArticleen_US
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