Bing–Neel syndrome: A rare complication of waldenstrom macroglobulinemia

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dc.contributor.authorKudva, Ranjinien_US
dc.contributor.authorMonappa, Vidyaen_US
dc.contributor.authorMenon, Girishen_US
dc.date.accessioned2025-08-13T11:40:47Z
dc.date.available2025-08-13T11:40:47Z
dc.date.issued2025-06
dc.description.abstractCentral nervous system involvement is a rare complication of Waldenstrom macroglobulinemia (WM) accounting for 1–2% cases. This syndrome is called Bing–Neel syndrome (BNS) after the people who first described it in 1936. Although WM has a good prognosis, with the onset of this syndrome, most patients fare poorly with a high mortality rate. A 77/male, a known case of WM, presented with left upper limb weakness of 2 weeks duration. Magnetic resonance imaging brain showed diffuse pachymeningeal thickening along bilateral frontoparietal convexity. Biopsy showed lymphoplasmacytic lymphoma favoring a diagnosis of BNS. The patient was started on chemotherapy (rituximab + ibrutinib). At 3 months following diagnosis, the patient was admitted with Gram?negative septicemic shock and failed to recover from it. BNS is a rare complication of WM, associated with poor prognosis and an aggressive clinical course. It can occur during the course of treatment of WM, as was seen in this case. Accurate diagnosis with appropriate treatment plays a crucial role in patient management.en_US
dc.identifier.affiliationsDepartment of Pathology, Kasturba Medical College Manipal, Manipal Academy of Higher Education, Manipal, Karnataka, Indiaen_US
dc.identifier.affiliationsDepartment of Pathology, Kasturba Medical College Manipal, Manipal Academy of Higher Education, Manipal, Karnataka, Indiaen_US
dc.identifier.affiliationsDepartment Neurosurgery, Kasturba Medical College and Kasturba Hospital, Manipal Academy of Higher Education, Manipal, Karnataka, Indiaen_US
dc.identifier.citationKudva Ranjini, Monappa Vidya, Menon Girish . Bing–Neel syndrome: A rare complication of waldenstrom macroglobulinemia. Indian Journal of Pathology & Microbiology. 2025 Jun; 68(2): 405-407en_US
dc.identifier.issn0377-4929
dc.identifier.issn0974-5130
dc.identifier.placeIndiaen_US
dc.identifier.urihttps://imsear.searo.who.int/handle/123456789/253953
dc.languageenen_US
dc.publisherWolters Kluwer - Medknowen_US
dc.relation.issuenumber2en_US
dc.relation.volume68en_US
dc.source.urihttps://doi.org/10.4103/ijpm.ijpm_997_23en_US
dc.subjectBing–Neel syndromeen_US
dc.subjectCNSen_US
dc.subjectlymphoplasmacytic lymphomaen_US
dc.subjectWaldenstrom macroglobulinemiaen_US
dc.titleBing–Neel syndrome: A rare complication of waldenstrom macroglobulinemiaen_US
dc.typeJournal Articleen_US
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