Successful multiple-dose methotrexate therapy for unruptured repeat ectopic pregnancy with high ?-human chorionic gonadotropin value: a case report

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dc.contributor.authorEzeike, A. C.en_US
dc.contributor.authorLiman, I. M.en_US
dc.contributor.authorBabandi, R. M.en_US
dc.contributor.authorAustin-Amadi, E. O.en_US
dc.contributor.authorNehemiah, M.en_US
dc.date.accessioned2024-09-24T09:20:30Z
dc.date.available2024-09-24T09:20:30Z
dc.date.issued2024-02
dc.description.abstractSuccessfully managing an unruptured ectopic pregnancy necessitates prioritizing the preservation of fertility as the primary objective. Medical management is traditionally considered to be more successful at lower �- human chorionic gonadotropin (HCG) values. However, there is emerging evidence that successful treatment can be achieved with modification of dosage regimen in the presence of high ?-HCG value. We reported the successful management of a case of unruptured repeat ectopic pregnancy in a patient with high ?-HCG. Mrs PA is a 25-year-old G4P0+3 with previous right salpingectomy due to ruptured ectopic gestation who presented with an ultrasound diagnosis of unruptured left tubal ectopic gestation at a gestational age of 6 weeks. The pre-treatment quantitative ?-HCG level was 7066 IU/l. She had multiple dose methotrexate therapy which was well tolerated with normalization of ?-HCG levels within 44 days. Hysterosalpingography done six (6) months post-treatment demonstrated patent left fallopian tube. She subsequently had spontaneous conception of an intrauterine pregnancy 16-months post-treatment. The pregnancy was carried to term and culminated in successful delivery at term. Multiple-dose chemotherapy was successful in this patient with high ?-HCG level with no reported adverse effect.en_US
dc.identifier.affiliationsDepartment of Obstetrics and Gynaecology, National Hospital, Abuja, Nigeriaen_US
dc.identifier.affiliationsDepartment of Obstetrics and Gynaecology, National Hospital, Abuja, Nigeriaen_US
dc.identifier.affiliationsDepartment of Obstetrics and Gynaecology, National Hospital, Abuja, Nigeriaen_US
dc.identifier.affiliationsDepartment of Obstetrics and Gynaecology, National Hospital, Abuja, Nigeriaen_US
dc.identifier.affiliationsDepartment of Obstetrics and Gynaecology, National Hospital, Abuja, Nigeriaen_US
dc.identifier.citationEzeike A. C., Liman I. M., Babandi R. M., Austin-Amadi E. O., Nehemiah M.. Successful multiple-dose methotrexate therapy for unruptured repeat ectopic pregnancy with high ?-human chorionic gonadotropin value: a case report. International Journal of Research in Medical Sciences. 2024 Feb; 12(2): 557-561en_US
dc.identifier.issn2320-6071
dc.identifier.issn2320-6012
dc.identifier.placeIndiaen_US
dc.identifier.urihttps://imsear.searo.who.int/handle/123456789/233748
dc.languageenen_US
dc.publisherMedip Academyen_US
dc.relation.issuenumber2en_US
dc.relation.volume12en_US
dc.source.urihttps://doi.org/10.18203/2320-6012.ijrms20240226en_US
dc.subjectUnruptureden_US
dc.subjectRepeaten_US
dc.subjectEctopic gestationen_US
dc.subjectMultiple doseen_US
dc.subject?-HCGen_US
dc.subjectMethotrexateen_US
dc.titleSuccessful multiple-dose methotrexate therapy for unruptured repeat ectopic pregnancy with high ?-human chorionic gonadotropin value: a case reporten_US
dc.typeJournal Articleen_US
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