Effect of Gmelina arborea Roxb in experimentally induced infl ammation and nociception.
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Date
2013-07
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Abstract
Background: Gmelina arborea Roxb (Verbenaceae), also known as “Gambhari”, is an important medicinal plant in the
Ayurveda. There are no meticulous scientifi c reports on effect of the plant on infl ammation and pain. Objective: To study
the anti-infl ammatory and anti-nociceptive properties of aqueous extracts (AE) and methanol extracts (ME) of G. arborea.
Materials and Methods: The AE and ME of stembark of G. arborea was prepared by cold maceration and Soxhlet extraction
technique respectively. Anti-infl ammatory activity was determined in Wistar albino rats in a model of acute plantar
infl ammation induced by carrageenan. The anti-nociceptive activity was evaluated by using hot plate test and writhing
test in Swiss albino mice. Signifi cant differences between the experimental groups were assessed by analysis of variance.
Results: AE and ME at dose of 500 mg/kg showed maximum inhibition in carrageenan induced infl ammation up to 30.15
and 31.21% respectively. In hot plate test, the AE and ME showed the maximum response of 8.8 ± 0.97 (P < 0.01) and
8.2 ± 1.24 (P < 0.01) respectively at dose of 500 mg/kg when compared with control. AE showed maximum inhibition of
writhing response (84.3%) as compared to ME (77.9%) in writhing test at a dose of 500 mg/kg. Conclusion: The fi ndings
suggested that G. arborea possess signifi cant anti-infl ammatory and anti-nociceptive activities.
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Keywords
Analgesic, anti-nociceptive, Gmelina arborea, hot plate test, hot plate test, writhing test
Citation
Kulkarni Yogesh A, Panjabi Ritesh, Patel Vishvas, Tawade Aditi, Gokhale Alok.Effect of Gmelina arborea Roxb in experimentally induced infl ammation and nociception. Journal of Ayurveda and Integrative Medicine. 2013 July-Sept; 4(3): 152-157.