Gastrointestinal problems at high altitude.

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dc.contributor.authorAnand, A Cen_US
dc.contributor.authorSashindran, V Ken_US
dc.contributor.authorMohan, Latikaen_US
dc.date.accessioned2006-10-05en_US
dc.date.accessioned2009-06-04T03:23:58Z
dc.date.available2006-10-05en_US
dc.date.available2009-06-04T03:23:58Z
dc.date.issued2006-10-05en_US
dc.description58 references.en_US
dc.description.abstractGastrointestinal (GI) problems at high altitude are commonplace. The manifestations differ considerably in short-term visitors, long-term residents and native highlanders. Ethnic food habits and social norms also play a role in causing GI dysfuntion. Symptoms like nausea and vomiting are common manifestations of acute mountain sickness and are seen in 81.4% short-term visitors like mountaineers. Anorexia is almost universal and has a mutifactorial causation including effect of hormones like leptin and cholecystokinin and also due to hypoxia itself. Dyspepsia and flatulence are other common symptoms. Diarrhoea, often related to poor hygiene and sanitation is also frequently seen especially among the short-term visitors. Peptic ulceration and upper gastro-intestinal haemorrhage are reported to be common in native highlanders in the' Peruvian Andes (9.6/10000 population per year) and also from Ladakh in India. A hig h incidence o f gastriccarcinoma is also reported, especially from Bolivia (138.2 cases per 10000 population per year). Megacolon and sigmoid volvulus are common lower GI disorders at high altitude. The latter accounted for 79% of all intestinal obstructions at a Bolivian hospital. Thrombosis of the portosystemic vascultature and splenic hematomas has been reported from India. Malnutrition is multifactorial and mainly due to hypoxia. Fat malabsorption is probably significant only at altitudes > 5000m. Neonatal hyperbilirubinemia was found to be four times more common in babies born at high altitude in Colorado than at sea level. Gall stones disease is common in Peruvian highlands. A high seroprevalence of antibodies to H pylori (95%) has been found in Ladakh but its correlation to the prevalence of upper gastro-intestinal disease has not been proven.en_US
dc.description.affiliationDept of Internal Medicine Armed Forces Medical College, Pune.en_US
dc.identifier.citationAnand AC, Sashindran VK, Mohan L. Gastrointestinal problems at high altitude. Tropical Gastroenterology. 2006 Oct-Dec; 27(4): 147-53en_US
dc.identifier.urihttps://imsear.searo.who.int/handle/123456789/124251
dc.language.isoengen_US
dc.source.urihttps://www.tropicalgastro.comen_US
dc.subject.meshAltitudeen_US
dc.subject.meshAltitude Sickness --complicationsen_US
dc.subject.meshBiliary Tract Diseases --etiologyen_US
dc.subject.meshGastrointestinal Diseases --etiologyen_US
dc.subject.meshHematoma --etiologyen_US
dc.subject.meshHumansen_US
dc.subject.meshMalabsorption Syndromes --etiologyen_US
dc.subject.meshSplanchnic Circulationen_US
dc.subject.meshSplenic Diseases --etiologyen_US
dc.subject.meshVascular Diseases --etiologyen_US
dc.titleGastrointestinal problems at high altitude.en_US
dc.typeJournal Articleen_US
dc.typeReviewen_US
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