Comparative in vitro activity of fluoroquinolones against Mycobacterium tuberculosis.

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dc.contributor.authorKarak, Ken_US
dc.contributor.authorDe, P Ken_US
dc.date.accessioned1995-04-01en_US
dc.date.accessioned2009-05-27T08:26:43Z
dc.date.available1995-04-01en_US
dc.date.available2009-05-27T08:26:43Z
dc.date.issued1995-04-01en_US
dc.description.abstractSixty clinical isolates of M. tuberculosis, 24 susceptible and 36 resistant to conventional primary antituberculous drugs, were tested against four fluoroquinolones (ciprofloxacin, ofloxacin, pefloxacin and norfloxacin). Ofloxacin and ciprofloxacin were found to be the most active, with minimum inhibitory concentration (MIC) of 0.6 mg/l or less to all strains tested. Strains resistant to isoniazid and other antitubercular drugs also showed more or less equal MICs for these two drugs. Mycobacterium tuberculosis H37 Rv showed MIC < 0.6 mg/l on each occasion. Other agents viz., norfloxacin and pefloxacin showed lesser activity against all these strains tested in comparison to ciprofloxacin and ofloxacin.en_US
dc.description.affiliationDepartment of Pathology & Microbiology, IPGME & R, Calcutta.en_US
dc.identifier.citationKarak K, De PK. Comparative in vitro activity of fluoroquinolones against Mycobacterium tuberculosis. Indian Journal of Medical Research. 1995 Apr; 101(): 147-9en_US
dc.identifier.urihttps://imsear.searo.who.int/handle/123456789/24470
dc.language.isoengen_US
dc.source.urihttps://icmr.nic.in/ijmr/ijmr.htmen_US
dc.subject.meshAnti-Infective Agents --pharmacologyen_US
dc.subject.meshFluoroquinolonesen_US
dc.subject.meshHumansen_US
dc.subject.meshMicrobial Sensitivity Testsen_US
dc.subject.meshMycobacterium tuberculosis --drug effectsen_US
dc.titleComparative in vitro activity of fluoroquinolones against Mycobacterium tuberculosis.en_US
dc.typeComparative Studyen_US
dc.typeJournal Articleen_US
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