Practical value of MIB-1 index in predicting behavior of astrocytomas.
dc.contributor.author | Ambroise, M Moses | |
dc.contributor.author | Khosla, Charu | |
dc.contributor.author | Ghosh, Mitra | |
dc.contributor.author | Mallikarjuna, V S | |
dc.contributor.author | Annapurneswari, S | |
dc.date.accessioned | 2012-10-11T07:40:29Z | |
dc.date.available | 2012-10-11T07:40:29Z | |
dc.date.issued | 2011-07 | |
dc.description.abstract | Background : The MIB-1 labeling index (LI) has proved to be useful in assigning grading and prognosis to astrocytomas. The purpose of our study was to analyze the utility of MIB-1 LI in differentiating astrocytomas of varying grades and the possible relationships of MIB-1 LI with clinical parameters like age and sex. We also wanted to study the prognostic role of MIB-1 index in predicting behavior of astrocytomas. Materials and Methods : Our study included 145 patients with astrocytic tumors of varying grades. Immunolabeling for all patients was done using MIB-1 antibody. Survival data could be obtained for 64 patients. A Mann-Whitney U test was used to test the difference in MIB-1 LI between different histological grades. The univariate analysis was done by the Kaplan-Meier method, and the multivariate analysis for survival was performed using the Cox proportional hazard model. Results : Significant differences were noted in mean MIB-1 LI of high-grade and low-grade diffuse astrocytomas. MIB-1 LI did not vary significantly with age and sex. Univariate analysis showed favorable prognostic factors for low histopathological grade, young patient age and low MIB-1 LI; however, multivariate analysis showed that only histopathological grade had independent prognostic significance. Conclusions : Our study proves that MIB-1 LI is not dependent on factors like age and sex and is solely dependent on histological grade. Though the average level of MIB-1 LI varies considerably in the different grades of astrocytomas, considerable overlap can be observed between them. MIB-1 LI is a very useful adjunct to the histopathological diagnosis and can be of great help in situations where the clinical and radiological findings do not correlate with histological diagnosis. | en_US |
dc.identifier.citation | Ambroise M Moses, Khosla Charu, Ghosh Mitra, Mallikarjuna V S, Annapurneswari S. Practical value of MIB-1 index in predicting behavior of astrocytomas. Indian Journal of Pathology & Microbiology. 2011 Jul-Sept 54(3): 520-525. | en_US |
dc.identifier.uri | https://imsear.searo.who.int/handle/123456789/142035 | |
dc.language.iso | en | en_US |
dc.source.uri | https://www.ijpmonline.org/article.asp?issn=0377-4929;year=2011;volume=54;issue=3;spage=520;epage=525;aulast=Ambroise | en_US |
dc.subject | Astrocytomas | en_US |
dc.subject | Ki-67 | en_US |
dc.subject | MIB-1 LI | en_US |
dc.subject | prognostic value | en_US |
dc.subject.mesh | Adolescent | |
dc.subject.mesh | Adult | |
dc.subject.mesh | Astrocytoma --diagnosis | |
dc.subject.mesh | Astrocytoma --mortality | |
dc.subject.mesh | Astrocytoma --pathology | |
dc.subject.mesh | Child | |
dc.subject.mesh | Female | |
dc.subject.mesh | Humans | |
dc.subject.mesh | Immunohistochemistry --methods | |
dc.subject.mesh | Male | |
dc.subject.mesh | Microscopy | |
dc.subject.mesh | Middle Aged | |
dc.subject.mesh | Prognosis | |
dc.subject.mesh | Severity of Illness Index | |
dc.subject.mesh | Survival Analysis | |
dc.subject.other | Ubiquitin-Protein Ligases --analysis | |
dc.title | Practical value of MIB-1 index in predicting behavior of astrocytomas. | en_US |
dc.type | Article | en_US |