Practical value of MIB-1 index in predicting behavior of astrocytomas.

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dc.contributor.authorAmbroise, M Moses
dc.contributor.authorKhosla, Charu
dc.contributor.authorGhosh, Mitra
dc.contributor.authorMallikarjuna, V S
dc.contributor.authorAnnapurneswari, S
dc.date.accessioned2012-10-11T07:40:29Z
dc.date.available2012-10-11T07:40:29Z
dc.date.issued2011-07
dc.description.abstractBackground : The MIB-1 labeling index (LI) has proved to be useful in assigning grading and prognosis to astrocytomas. The purpose of our study was to analyze the utility of MIB-1 LI in differentiating astrocytomas of varying grades and the possible relationships of MIB-1 LI with clinical parameters like age and sex. We also wanted to study the prognostic role of MIB-1 index in predicting behavior of astrocytomas. Materials and Methods : Our study included 145 patients with astrocytic tumors of varying grades. Immunolabeling for all patients was done using MIB-1 antibody. Survival data could be obtained for 64 patients. A Mann-Whitney U test was used to test the difference in MIB-1 LI between different histological grades. The univariate analysis was done by the Kaplan-Meier method, and the multivariate analysis for survival was performed using the Cox proportional hazard model. Results : Significant differences were noted in mean MIB-1 LI of high-grade and low-grade diffuse astrocytomas. MIB-1 LI did not vary significantly with age and sex. Univariate analysis showed favorable prognostic factors for low histopathological grade, young patient age and low MIB-1 LI; however, multivariate analysis showed that only histopathological grade had independent prognostic significance. Conclusions : Our study proves that MIB-1 LI is not dependent on factors like age and sex and is solely dependent on histological grade. Though the average level of MIB-1 LI varies considerably in the different grades of astrocytomas, considerable overlap can be observed between them. MIB-1 LI is a very useful adjunct to the histopathological diagnosis and can be of great help in situations where the clinical and radiological findings do not correlate with histological diagnosis.en_US
dc.identifier.citationAmbroise M Moses, Khosla Charu, Ghosh Mitra, Mallikarjuna V S, Annapurneswari S. Practical value of MIB-1 index in predicting behavior of astrocytomas. Indian Journal of Pathology & Microbiology. 2011 Jul-Sept 54(3): 520-525.en_US
dc.identifier.urihttps://imsear.searo.who.int/handle/123456789/142035
dc.language.isoenen_US
dc.source.urihttps://www.ijpmonline.org/article.asp?issn=0377-4929;year=2011;volume=54;issue=3;spage=520;epage=525;aulast=Ambroiseen_US
dc.subjectAstrocytomasen_US
dc.subjectKi-67en_US
dc.subjectMIB-1 LIen_US
dc.subjectprognostic valueen_US
dc.subject.meshAdolescent
dc.subject.meshAdult
dc.subject.meshAstrocytoma --diagnosis
dc.subject.meshAstrocytoma --mortality
dc.subject.meshAstrocytoma --pathology
dc.subject.meshChild
dc.subject.meshFemale
dc.subject.meshHumans
dc.subject.meshImmunohistochemistry --methods
dc.subject.meshMale
dc.subject.meshMicroscopy
dc.subject.meshMiddle Aged
dc.subject.meshPrognosis
dc.subject.meshSeverity of Illness Index
dc.subject.meshSurvival Analysis
dc.subject.otherUbiquitin-Protein Ligases --analysis
dc.titlePractical value of MIB-1 index in predicting behavior of astrocytomas.en_US
dc.typeArticleen_US
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