Flunarizine versus topiramate in migraine prophylaxis and their effect on psychomotor ability: A prospective open-label study

Simple item page
dc.contributor.authorDixit, Aen_US
dc.contributor.authorPandey, Den_US
dc.contributor.authorKhan, NFen_US
dc.contributor.authorSingh, Cen_US
dc.contributor.authorPathak, Aen_US
dc.contributor.authorYadav, R.en_US
dc.date.accessioned2024-12-02T11:33:40Z
dc.date.available2024-12-02T11:33:40Z
dc.date.issued2024-10
dc.description.abstractBackground: About 9% of the overall population suffers from migraine headaches, with a female majority. For the prevention of migraines, the two most often prescribed drugs are topiramate (TPM) and flunarizine. Regarding TPM and flunarizine’s long-term efficacy, safety, and adverse effects on migraine prevention, little is known. To evaluate the effectiveness of flunarizine against TPM in migraine prophylaxis and its impact on psychomotor ability, the current study was designed. Aims and Objectives: The aim of the study was to compare the efficacy of flunarizine and TPM in the prophylaxis of migraine and to assess change in the psychomotor ability of the brain using different psychomotor analysis scoring systems. Materials and Methods: A comparative, open-label, and prospective study was carried out on patients with chronic migraine from the outpatient department of the neurology department at Uttar Pradesh University of Medical Sciences, Saifai, Uttar Pradesh, with flunarizine and TPM treatment (n = 20/group) for 2 months. Data regarding patient’s scores of headache severity on the Visual Analogue Scale (VAS), digit later substitution test, 6 letter cancellation test, digit span test, mathematical ability test, and flicker fusion apparatus test were recorded and analyzed. Results: When compared to the baseline, the mean±standard deviation pain severity score on the VAS was 2.9 ± 0.8 in the flunarizine group and 3.7 ± 1.4 in the TPM group, with a P < 0.001. Furthermore, the flunarizine group showed less decline in performances in the scores of each psychomotor test as compared with the scores of the TPM treatment group when baseline values were compared at 1 and 2 months. Conclusion: Flunarizine is well tolerated, has a better safety profile, and has less cognitive decline as compared to TPM.en_US
dc.identifier.affiliationsDepartment of Pharmacology, U P University of Medical Sciences, Etawah, Uttar Pradesh, Indiaen_US
dc.identifier.affiliationsDepartment of Pharmacology, U P University of Medical Sciences, Etawah, Uttar Pradesh, Indiaen_US
dc.identifier.affiliationsDepartment of Pharmacology, U P University of Medical Sciences, Etawah, Uttar Pradesh, Indiaen_US
dc.identifier.affiliationsDepartment of Pharmacology, U P University of Medical Sciences, Etawah, Uttar Pradesh, Indiaen_US
dc.identifier.affiliationsDepartment of Pharmacology, U P University of Medical Sciences, Etawah, Uttar Pradesh, Indiaen_US
dc.identifier.affiliationsDepartment of Neurology, U P University of Medical Sciences, Etawah, Uttar Pradesh, Indiaen_US
dc.identifier.citationDixit A, Pandey D, Khan NF, Singh C, Pathak A, Yadav R.. Flunarizine versus topiramate in migraine prophylaxis and their effect on psychomotor ability: A prospective open-label study . National Journal of Physiology, Pharmacy and Pharmacology. 2024 Oct; 14(10): 2198-2203en_US
dc.identifier.issn2231-3206
dc.identifier.issn2320-4672
dc.identifier.placeIndiaen_US
dc.identifier.urihttps://imsear.searo.who.int/handle/123456789/240407
dc.languageenen_US
dc.publisher?Eldaghayes Publisheren_US
dc.relation.issuenumber10en_US
dc.relation.volume14en_US
dc.source.urihttps://dx.doi.org/10.5455/njppp.2024.14.05194202401072024en_US
dc.subjectChronic Migraineen_US
dc.subjectVisual Analogue Scaleen_US
dc.subjectFlicker Fusion Apparatus Testen_US
dc.titleFlunarizine versus topiramate in migraine prophylaxis and their effect on psychomotor ability: A prospective open-label studyen_US
dc.typeJournal Articleen_US
Files
Original bundle
Now showing 1 - 1 of 1
No Thumbnail Available
Name:
njppp2024v14n10p2198.pdf
Size:
269.13 KB
Format:
Adobe Portable Document Format
Download
Collections
National Journal of Physiology, Pharmacy and Pharmacology