ANCA: serology in Wegener's granulomatosis.

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dc.contributor.authorPradhan, Vandana Den_US
dc.contributor.authorBadakere, S Sen_US
dc.contributor.authorGhosh, Ken_US
dc.contributor.authorAlmeida, Aen_US
dc.date.accessioned2005-07-03en_US
dc.date.accessioned2009-05-29T04:39:03Z
dc.date.available2005-07-03en_US
dc.date.available2009-05-29T04:39:03Z
dc.date.issued2005-07-03en_US
dc.description.abstractBACKGROUND AND OBJECTIVES: Wegener's granulomatosis (WG) is being increasingly diagnosed in India, which exists in two forms, the 'limited Wegener's granulomatosis' (LWG) having upper respiratory tract (URT) and lower respiratory tract (LRT) involvement and the 'classical Wegener's granulomatosis' (CWG), with the triad of URT, LRT involvement along with kidney involvement. Cytoplasmic ANCA (C-ANCA) or anti-Proteinase3 (anti-PR3), which is highly diagnostic for WG, rarely perinuclear ANCA (P-ANCA) may exist. AIMS: To detect anti-neutrophil cytoplasmic antibodies (ANCA) and correlate it with serological, hematological parameters, and the Birmingham Vasculitis Activity Score (BVAS). SETTINGS AND DESIGN: Twenty-three clinically and histopathologically proven WG (16 CWG, 7 LWG) were studied. MATERIAL AND METHODS: C-ANCA and P-ANCA patterns were identified by immunofluorescence and specificities were confirmed by 'alpha granule' enzyme linked immunosorbent assay (ELISA), anti-PR3, anti-MPO (myeloperoxidase) and anti-Lactoferrin (anti-LF) by ELISA. RESULTS: LRT involvement was seen in 91.3%, URT in 78.3%, and renal manifestations in 69.6% cases. The BVAS in CWG was significantly higher than BVAS in the LWG. Decreased hemoglobin, increased WBC counts, ESR, CRP and Creatinine were seen in CWG as compared to LWG. The C-ANCA was present in 65.2% patients and P-ANCA in 13% cases. Anti-PR3 was seen in 69.6% patients and anti-LF in 17.4% cases. Severity of disease and ANCA was higher in CWG than in LWG. CONCLUSIONS: Vasculitis syndromes are known to overlap and many go undetected; therefore ANCA testing, along with the clinical and histopathological observations may be helpful in early detection and management of WG cases.en_US
dc.description.affiliationDepartment of Autoimmune Disorders, Institute of Immunohaematology, Indian Council of Medical Research, K. E. M. Hospital, Mumbai, India. pradhanv69@rediffmail.comen_US
dc.identifier.citationPradhan VD, Badakere SS, Ghosh K, Almeida A. ANCA: serology in Wegener's granulomatosis. Indian Journal of Medical Sciences. 2005 Jul; 59(7): 292-300en_US
dc.identifier.urihttps://imsear.searo.who.int/handle/123456789/66724
dc.language.isoengen_US
dc.source.urihttps://www.indianjmedsci.orgen_US
dc.subject.meshAntibodies, Antineutrophil Cytoplasmic --blooden_US
dc.subject.meshEnzyme-Linked Immunosorbent Assayen_US
dc.subject.meshFemaleen_US
dc.subject.meshFluorescent Antibody Technique, Indirecten_US
dc.subject.meshHumansen_US
dc.subject.meshLactoferrin --blooden_US
dc.subject.meshMaleen_US
dc.subject.meshMyeloblastinen_US
dc.subject.meshPeroxidase --blooden_US
dc.subject.meshSerine Endopeptidases --blooden_US
dc.subject.meshWegener Granulomatosis --blooden_US
dc.titleANCA: serology in Wegener's granulomatosis.en_US
dc.typeJournal Articleen_US
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