Carbohydrate induced modulation of cell membrane. IV: Interaction with mucin and fucoidan totally immobilizes the human platelet membrane.

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dc.contributor.authorHajela, Ken_US
dc.contributor.authorKayestha, Ren_US
dc.contributor.authorSumati,en_US
dc.date.accessioned1996-08-01en_US
dc.date.accessioned2009-05-27T09:25:32Z
dc.date.available1996-08-01en_US
dc.date.available2009-05-27T09:25:32Z
dc.date.issued1996-08-01en_US
dc.description.abstractP selectins and E selectins are cell adhesion molecules that mediate the interaction of platelets and endothelial cells with neutrophils and monocytes. The proposed ligands for these receptors contain the Le(x) core, sialic acid and sulfated fucose. In this paper we report that binding of sialic acid markedly restricts the mobility of membrane proteins and lipids as studied by EPR spectroscopy using spin probes. Binding of mucin and fucoidan totally restricts the mobility probably due to cross-linking of the surface lectins. Binding of these ligands also resulted in an increase in the cytoplasmic viscosity.en_US
dc.description.affiliationSchool of Life Sciences, Devi Ahilya Vishwavidyalaya, Indore, India.en_US
dc.identifier.citationHajela K, Kayestha R, Sumati . Carbohydrate induced modulation of cell membrane. IV: Interaction with mucin and fucoidan totally immobilizes the human platelet membrane. Indian Journal of Biochemistry & Biophysics. 1996 Aug; 33(4): 308-10en_US
dc.identifier.urihttps://imsear.searo.who.int/handle/123456789/27467
dc.language.isoengen_US
dc.source.urihttps://https://www.niscair.res.in/ScienceCommunication/ResearchJournals/rejour/ijbb/ijbb0.aspen_US
dc.subject.meshBlood Platelets --chemistryen_US
dc.subject.meshCell Membrane --chemistryen_US
dc.subject.meshElectron Spin Resonance Spectroscopyen_US
dc.subject.meshHumansen_US
dc.subject.meshLigandsen_US
dc.subject.meshMembrane Lipids --chemistryen_US
dc.subject.meshMembrane Proteins --chemistryen_US
dc.subject.meshMucins --pharmacologyen_US
dc.subject.meshPolysaccharides --pharmacologyen_US
dc.subject.meshSelectins --metabolismen_US
dc.titleCarbohydrate induced modulation of cell membrane. IV: Interaction with mucin and fucoidan totally immobilizes the human platelet membrane.en_US
dc.typeIn Vitroen_US
dc.typeJournal Articleen_US
dc.typeResearch Support, Non-U.S. Gov'ten_US
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