Comparison of prevention of parent-to-child HIV transmission programme & national biennial HIV sentinel surveillance data for tracking HIV epidemic in India

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dc.contributor.authorLakshmi, P. V. M.en_US
dc.contributor.authorElangovan, Arumuganen_US
dc.contributor.authorBhatnagar, Tarunen_US
dc.contributor.authorKant, Shashien_US
dc.contributor.authorRai, Sanjay K.en_US
dc.contributor.authorSaha, Malay K.en_US
dc.contributor.authorGodbole, Sheelaen_US
dc.contributor.authorMehendale, Sanjayen_US
dc.contributor.authorSingh, Y. Maniharen_US
dc.contributor.authorVerma, Vinitaen_US
dc.contributor.authorRajan, Shobinien_US
dc.contributor.authorKumar, Rajeshen_US
dc.date.accessioned2023-08-19T04:52:30Z
dc.date.available2023-08-19T04:52:30Z
dc.date.issued2022-12
dc.description.abstractBackground & objectives: HIV sentinel surveillance (HSS) among antenatal women in India has been used to track the epidemic for many years. However, reliable tracking at the local level is not possible as ANC sentinel sites are limited in number and cover a smaller sample size at each site. Prevention of parent-to-child-transmission (PPTCT) programme data has a potential advantage due to better geographical coverage, which could provide more precise HIV case estimates; therefore, we compared HSS ANC data with PPTCT programme data for HIV tracking. Methods: Out of the 499 surveillance sites, where HSS and PPTCT programme was being conducted in 2015, 210 sites (140 urban and 70 rural) were selected using a stratified random sampling method. HSS (n=72,981) and PPTCT (n=112,832) data records were linked confidentially. The sociodemographic characteristics of HSS and PPTCT attendees were compared. HIV prevalence from HSS ANC was compared with the PPTCT programme data using Chi-square test. State- and site-level correlation of HIV prevalence was also done. Concordance between HSS and PPTCT HIV positivity was estimated using kappa statistics. Results: The age distribution of HSS and PPTCT attendees was similar (range: 23 to 27 yr); however, HSS ANC participants were better educated, whereas PPTCT recorded a higher proportion of homemakers. The correlation of HIV prevalence between HSS and PPTCT was high (r=0.9) at the State level and moderate at the site level (r=0.7). The HIV positivity agreement between HSS ANC and PPTCT was good (kappa=0.633). A similar prevalence was reported across 26 States, whereas PPTCT had a significantly lower prevalence than HSS in three States where PPTCT coverage was low. Overall HIV prevalence was 0.31 per cent in HSS and 0.22 per cent in PPTCT (P<0.001). Interpretation & conclusions: High-quality PPTCT programme data can provide reliable HIV trends in India. An operational framework for PPTCT-based surveillance should be pilot-tested in a phased manner before replacing HSS with PPTCT.en_US
dc.identifier.affiliationsDepartment of Community Medicine & School of Public Health, Postgraduate Institute of Medical Education & Research, Chandigarhen_US
dc.identifier.affiliationsComputing & Information Science Divisionen_US
dc.identifier.affiliationsICMR School of Public Health, National Institute of Epidemiology-Indian Council of Medical Research, Chennai, Tamil Naduen_US
dc.identifier.affiliationsCentre for Community Medicine, All India Institute of Medical Sciencesen_US
dc.identifier.affiliationsDepartment of Evaluation & Operational Research, Strategic Information, National AIDS Control Organization, Ministry of Health & Family Welfare, New Delhien_US
dc.identifier.affiliationsDivision of Virology, National HIV Reference Laboratory, ICMR-National Institute of Cholera & Enteric Diseases, Kolkata, West Bengalen_US
dc.identifier.affiliationsICMR-National AIDS Research Institute, ICMR-National Institute of Virology, Puneen_US
dc.identifier.affiliationsP.D. Hinduja Hospital & Medical Research Center, Mumbai, Maharashtra &en_US
dc.identifier.affiliationsDepartment of Community Medicine-Epidemiology Unit, Regional Institute of Medical Sciences, Imphal West, Manipur, Indiaen_US
dc.identifier.citationLakshmi P. V. M., Elangovan Arumugan, Bhatnagar Tarun, Kant Shashi, Rai Sanjay K., Saha Malay K., Godbole Sheela, Mehendale Sanjay, Singh Y. Manihar, Verma Vinita, Rajan Shobini, Kumar Rajesh. Comparison of prevention of parent-to-child HIV transmission programme & national biennial HIV sentinel surveillance data for tracking HIV epidemic in India. Indian Journal of Medical Research. 2022 Dec; 156(6): 742-749en_US
dc.identifier.issn0971-5916
dc.identifier.placeIndiaen_US
dc.identifier.urihttps://imsear.searo.who.int/handle/123456789/223702
dc.languageenen_US
dc.publisherWolters Kluwer – Medknowen_US
dc.relation.issuenumber6en_US
dc.relation.volume156en_US
dc.source.urihttps://doi.org/10.4103/ijmr.ijmr_3311_21en_US
dc.subjectHIVen_US
dc.subjectprevalenceen_US
dc.subjectpreventionen_US
dc.subjectsentinel surveillanceen_US
dc.titleComparison of prevention of parent-to-child HIV transmission programme & national biennial HIV sentinel surveillance data for tracking HIV epidemic in Indiaen_US
dc.typeJournal Articleen_US
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