Repurcussions of Concurrent Chemoradiotherapy for Head and Neck Cancers

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dc.contributor.authorC, Satish Kumaren_US
dc.contributor.authorV, Hemanthen_US
dc.contributor.authorM, Prakashen_US
dc.contributor.authorF, Musarraten_US
dc.contributor.authorP, Preetham A.en_US
dc.date.accessioned2020-01-02T06:11:30Z
dc.date.available2020-01-02T06:11:30Z
dc.date.issued2019-05
dc.description.abstractCancer is a potentially lethal disorder with abnormal cell growth and metastasis, warranting multimodal treatment owing to its diversity and complexity. Head and neck cancers are physically and emotionally devastating disease, with profound impact on the most fundamental activities of the subjects’ daily life such as the ability to speak, breathe, eat, drink, and socialize. The side-effects of radiotherapy and chemotherapy get superimposed on the existing problems and cause new problems resulting in significant morbidity and suffering. Methods: This Prospective Observational study was conducted at the Department of ENT, Southern Railway Headquarters Hospital, Chennai, India. All subjects were evaluated for toxicities using RTOG/EORTC toxicity criteria and Common Toxicity Criteria (CTC). Results: Hypopharynx was the most common site of malignancy observed (31.6 %). Pain (90%) and appetite loss (84.2%) secondary to Mucositis and Xerostomia were the most predominant, serious and lasting adverse effects noted. Subjects also experienced markedly altered smell (63%) and taste (78%). Skin changes and alopecia was observed in all the subjects. Overall treatment duration was prolonged in 78.9% owing to severe toxicities, which necessitated withholding of last few cycles of chemotherapy. Conclusion: Subjects receiving concurrent Chemo-Radiotherapy experience a substantial number of treatment related adverse events, which had considerable effect on their Quality of life.en_US
dc.identifier.affiliationsAssistant Professor, Department of ENT, Indira Gandhi Medical college & Research Institute, Puducherry.en_US
dc.identifier.affiliationsDivisional Medical Officer, Department of ENT, South Western Railways, Bangalore, Karnataka.en_US
dc.identifier.affiliationsAssistant Professor, Department of Community Medicine, Indira Gandhi Medical college & Research Institute, Puducherry.en_US
dc.identifier.affiliationsAssistant Chief Health Director, Department of ENT, Southern Railway Headquarters Hospital, Chennai, Tamilnadu.en_US
dc.identifier.citationC Satish Kumar, V Hemanth, M Prakash, F Musarrat, P Preetham A.. Repurcussions of Concurrent Chemoradiotherapy for Head and Neck Cancers. Annals of International medical and Dental Research. 2019 May; 5(3): 1-6en_US
dc.identifier.issn2395-2822
dc.identifier.issn2395-2814
dc.identifier.placeIndiaen_US
dc.identifier.urihttps://imsear.searo.who.int/handle/123456789/189245
dc.languageenen_US
dc.publisherSociety for Health Care & Research Developmenten_US
dc.relation.issuenumber3en_US
dc.relation.volume5en_US
dc.source.urihttps://doi.org/10.21276/aimdr.2019.5.3.EN1en_US
dc.subjectConcurrent chemoradiotherapyen_US
dc.subjectmucositisen_US
dc.subjectquality of livingen_US
dc.subjectxerostomiaen_US
dc.titleRepurcussions of Concurrent Chemoradiotherapy for Head and Neck Cancersen_US
dc.typeJournal Articleen_US
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