Association between chronic renal disease and psoriasis risk in diabetes patients: A Korean population-based study

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dc.contributor.authorYoo, SAen_US
dc.contributor.authorSayo, MIAen_US
dc.contributor.authorLee, JH.en_US
dc.date.accessioned2025-06-18T11:42:21Z
dc.date.available2025-06-18T11:42:21Z
dc.date.issued2025-04
dc.description.abstractBackground: Several studies have reported that psoriasis has a positive correlation with type 2 diabetes mellitus (DM). Understanding the risk of psoriasis in diabetic patients is significant because it allows for early intervention and potential insights into the common pathways between the two conditions. Objectives: We analysed the risk of psoriasis according to the estimated glomerular filtration rate (eGFR) and proteinuria level in DM patients using Korean population–based data. Methods: This study was a retrospective cohort study using data collected from the country in the form of exploratory data analysis. A total of 927,234 participants diagnosed with DM were enrolled. Patients under the age of 20 with existing psoriasis or psoriasis developed within 1 year and missing data were excluded. The development of psoriasis was the primary outcome within a follow-up period of 7.83 ± 1.68 years. Results: Of the 840,395 final participants, 28,010 (3.33%) patients developed psoriasis. In multivariate-adjusted Cox proportional hazards regression models, the DM patients with eGFR < 30 had a higher risk of psoriasis after adjustment (eGFR 60–90, hazard ratio [HR] 1 (Ref.); eGFR < 30, HR 1.173, 95% CI 1.089–1.264). In addition, there was an increased psoriatic risk of patients with DM and proteinuria after adjustment (negative, HR 1 (Ref.); 2+, HR 1.164, 95% CI 1.080– 1.254; 3+, HR 1.433, 95% CI 1.273–1.613; 4+, HR 1.508, 95% CI 1.177–1.931). Limitations: The severity of psoriasis was not measured since the occurrence of psoriasis was the outcome. Details of oral hypoglycaemic agents such as type and dose were not investigated. Conclusion: This study showed that a decrease in eGFR and aggravation of proteinuria increase the risk of psoriasis in diabetic patients. Therefore, by using eGFR and proteinuria as predictive risk factors of psoriasis in DM patients, early and proactive treatment may play a vital role in managing diabetic patients.en_US
dc.identifier.affiliationsDepartment of Dermatology, Seoul St. Mary’s Hospital, College of Medicine, The Catholic University of Korea, Seocho-gu, Seoul, Republic of Koreaen_US
dc.identifier.affiliationsDepartment of Dermatology, East Avenue Medical Center, Quezon City, Metro Manila, Philippinesen_US
dc.identifier.affiliationsDepartment of Dermatology, Seoul St. Mary’s Hospital, College of Medicine, The Catholic University of Korea, Seocho-gu, Seoul, Republic of Korea.en_US
dc.identifier.citationYoo SA, Sayo MIA, Lee JH.. Association between chronic renal disease and psoriasis risk in diabetes patients: A Korean population-based study. Indian Journal of Dermatology, Venereology and Leprology. 2025 Apr; 91(2): 152-157en_US
dc.identifier.issn0378-6323
dc.identifier.issn0973-3922
dc.identifier.placeIndiaen_US
dc.identifier.urihttps://imsear.searo.who.int/handle/123456789/249386
dc.languageenen_US
dc.publisherScientific Scholar on behalf of Indian Association of Dermatologists, Venereologists & Leprologists (IADVL), India.en_US
dc.relation.issuenumber2en_US
dc.relation.volume91en_US
dc.source.urihttps://dx.doi.org/10.25259/IJDVL_669_2023en_US
dc.subjectDiabetesen_US
dc.subjectepidemiologyen_US
dc.subjectchronicen_US
dc.subjectrenal failureen_US
dc.subjectproteinuriaen_US
dc.subjectpsoriasisen_US
dc.titleAssociation between chronic renal disease and psoriasis risk in diabetes patients: A Korean population-based studyen_US
dc.typeJournal Articleen_US
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