Defective erythropoietin production and reticulocyte response in acute Plasmodium falciparum malaria-associated anemia.

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dc.contributor.authorLeowattana, Wattanaen_US
dc.contributor.authorKrudsood, Srivichaen_US
dc.contributor.authorTangpukdee, Noppadonen_US
dc.contributor.authorBrittenham, Garyen_US
dc.contributor.authorLooareesuwan, Sornchaien_US
dc.date.accessioned2009-05-27T16:23:18Z
dc.date.available2009-05-27T16:23:18Z
dc.date.issued2008-07-09en_US
dc.descriptionThe Southeast Asian Journal of Tropical Medicine and Public Health.en_US
dc.description.abstractTo elucidate the relationship between falciparum malaria-associated anemia and serum erythropoietin (Epo) levels and reticulocyte response during acute malaria infection, 87 adults aged 18-65 years presenting with acute, uncomplicated malaria were examined on enrollment and for 28 days of follow-up. The 87 patients were divided into 2 groups: those with anemia (n = 45) and those without (n = 42). Serum samples were taken on admission (Day 0), then on Days 7, 21, and 28, to measure the reticulocyte count, absolute reticulocyte count, reticulocyte hemoglobin content, and erythropoietin level (Epo). The absolute reticulocyte counts for the anemic patients were significantly higher than for those without anemia on Days 0, 7, 21, and 28. The serum Epo levels for the anemic patients were significantly higher than the non-anemic group only on Day 0 (44.39 +/- 4.06 vs 25.91 +/- 4.86 mlU/ml, p < 0.001). Inadequate Epo production was found in 31.03% (27/87) of patients on Day 0, 37.93% (33/87) on Day 7, 43.67% (38/87) on Day 21, and 39.08% (34/87) on Day 28. These results indicate defective Epo production and reticulocyte response in adult patients suffering from acute P. falciparum malaria, which differs from pediatric patients. Our findings may provide the basis for further study into the choice of therapeutic strategies to treat acute P. falciparum malaria-associated anemia with recombinant human Epo to correct refractory anemia due to malaria.en_US
dc.description.affiliationDepartment of Clinical Tropical Medicine, Mahidol University, 420/6 Ratchawithi Road, Bangkok 10400, Thailand. dirctm@mahidol.ac.then_US
dc.identifier.citationLeowattana W, Krudsood S, Tangpukdee N, Brittenham G, Looareesuwan S. Defective erythropoietin production and reticulocyte response in acute Plasmodium falciparum malaria-associated anemia. The Southeast Asian Journal of Tropical Medicine and Public Health. 2008 Jul; 39(4): 581-8en_US
dc.identifier.urihttps://imsear.searo.who.int/handle/123456789/35094
dc.language.isoengen_US
dc.source.urihttps://www.tm.mahidol.ac.th/seameo/2008_39_4/01-4281.pdfen_US
dc.subject.meshAcute Diseaseen_US
dc.subject.meshAdolescenten_US
dc.subject.meshAdulten_US
dc.subject.meshAgeden_US
dc.subject.meshAnemia --blooden_US
dc.subject.meshErythropoietin --biosynthesisen_US
dc.subject.meshFemaleen_US
dc.subject.meshHematocriten_US
dc.subject.meshHumansen_US
dc.subject.meshLongitudinal Studiesen_US
dc.subject.meshMalaria, Falciparum --blooden_US
dc.subject.meshMaleen_US
dc.subject.meshMiddle Ageden_US
dc.subject.meshReticulocyte Counten_US
dc.subject.meshReticulocytes --physiologyen_US
dc.subject.meshYoung Adulten_US
dc.titleDefective erythropoietin production and reticulocyte response in acute Plasmodium falciparum malaria-associated anemia.en_US
dc.typeJournal Articleen_US
dc.typeResearch Support, N.I.H., Extramuralen_US
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